Additive manufacturing in drug delivery applications: A review

Reddy, R. Durga Prasad; Sharma, Varun

doi:10.1016/j.ijpharm.2020.119820

Cited by 80 publications

(39 citation statements)

References 264 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides that, based on the simulation result, non-uniformed hollow spaces pattern displayed favourable result that could be a reference for future research in order to design the suitable pattern for the 4D PLA model. The possible advanced applications of 4D printing are medical devices for stents placed into blood vessels, drug capsules that release medicine, home appliances for control and that adjust according to humidity and heat, footwear and clothes, implants for humans and animals made from biocompatible materials, soft robots that can be activated without reliance on an electric device, smart valves and sensors for infrastructure lines [178][179][180][181][182][183]. Adapted from Alief et al [177] with copyright permission of AIP Conference Proceedings.…”

Section: D and 4d Printings Of Pla Biocompositementioning

confidence: 99%

Polylactic Acid (PLA) Biocomposite: Processing, Additive Manufacturing and Advanced Applications

et al. 2021

View full text Add to dashboard Cite

Over recent years, enthusiasm towards the manufacturing of biopolymers has attracted considerable attention due to the rising concern about depleting resources and worsening pollution. Among the biopolymers available in the world, polylactic acid (PLA) is one of the highest biopolymers produced globally and thus, making it suitable for product commercialisation. Therefore, the effectiveness of natural fibre reinforced PLA composite as an alternative material to substitute the non-renewable petroleum-based materials has been examined by researchers. The type of fibre used in fibre/matrix adhesion is very important because it influences the biocomposites’ mechanical properties. Besides that, an outline of the present circumstance of natural fibre-reinforced PLA 3D printing, as well as its functions in 4D printing for applications of stimuli-responsive polymers were also discussed. This research paper aims to present the development and conducted studies on PLA-based natural fibre bio-composites over the last decade. This work reviews recent PLA-derived bio-composite research related to PLA synthesis and biodegradation, its properties, processes, challenges and prospects.

show abstract

Section: D and 4d Printings Of Pla Biocompositementioning

confidence: 99%

Polylactic Acid (PLA) Biocomposite: Processing, Additive Manufacturing and Advanced Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Besides traditional plastic components, this process has been adopted for a wide range of industries for innovative product development including soft magnets [62], drug delivery systems in the pharmaceutical field including personalized medicines [63][64][65][66], in the forensic comparative analysis [67], in complete electrochemical sensing devices fabrication [68], in 3D printed microfluidics [69] and to design and manufacturing of complex porous scaffolds for biomedical, and tissue engineering applications [70]. Moreover, it also fits well in the framework of primary and secondary recycling.…”

Section: Materials Extrusionmentioning

confidence: 99%

Additive Manufacturing of Polymer Materials: Progress, Promise and Challenges

et al. 2021

View full text Add to dashboard Cite

The use of additive manufacturing (AM) has moved well beyond prototyping and has been established as a highly versatile manufacturing method with demonstrated potential to completely transform traditional manufacturing in the future. In this paper, a comprehensive review and critical analyses of the recent advances and achievements in the field of different AM processes for polymers, their composites and nanocomposites, elastomers and multi materials, shape memory polymers and thermo-responsive materials are presented. Moreover, their applications in different fields such as bio-medical, electronics, textiles, and aerospace industries are also discussed. We conclude the article with an account of further research needs and future perspectives of AM process with polymeric materials.

show abstract

“…[110][111][112][113][114][115][116][117][118][119][120] The human microbiome is as unique as one's fingerprint, thus 3D printing could be a useful technique for manufacture of personalized microbiome therapeutics. [121][122][123][124][125][126][127] Such formulations could contain live microorganisms, for example oral films containing viable probiotics have been produced using inkjet printing. 128 3D printing of microbiome therapeutics remains in its infancy, and so ML can be well applied to efficiently optimize printing parameters; reducing the number of empirical experiments needed.…”

Section: Entities Altering the Microbiome Microenvironmentmentioning

confidence: 99%

Harnessing machine learning for development of microbiome therapeutics

et al. 2021

View full text Add to dashboard Cite

The last twenty years of seminal microbiome research has uncovered microbiota's intrinsic relationship with human health. Studies elucidating the relationship between an unbalanced microbiome and disease are currently published daily. As such, microbiome big data have become a reality that provide a mine of information for the development of new therapeutics. Machine learning (ML), a branch of artificial intelligence, offers powerful techniques for big data analysis and predictionmaking, that are out of reach of human intellect alone. This review will explore how ML can be applied for the development of microbiome-targeted therapeutics. A background on ML will be given, followed by a guide on where to find reliable microbiome big data. Existing applications and opportunities will be discussed, including the use of ML to discover, design, and characterize microbiome therapeutics. The use of ML to optimize advanced processes, such as 3D printing and in silico prediction of drug-microbiome interactions, will also be highlighted. Finally, barriers to adoption of ML in academic and industrial settings will be examined, concluded by a future outlook for the field.

show abstract

Additive manufacturing in drug delivery applications: A review

Cited by 80 publications

References 264 publications

Polylactic Acid (PLA) Biocomposite: Processing, Additive Manufacturing and Advanced Applications

Polylactic Acid (PLA) Biocomposite: Processing, Additive Manufacturing and Advanced Applications

Additive Manufacturing of Polymer Materials: Progress, Promise and Challenges

Harnessing machine learning for development of microbiome therapeutics

Contact Info

Product

Resources

About