EARLY studies on the circulation of the liver yielded a wealth of knowledge yet left many uncertainties. The minute vascular pattern can be seen in its natural physiological setting only in the intact liver of the live animal, and the methods of injection, perfusion and ligature of vessels available to the early investigators were therefore of limited value.
We report here a case of acute renal failure with nitrofurantoin-associated acute granulomatous interstitial nephritis (GIN), which was commenced as a long-term prophylactic agent for suspected recurrent urinary tract infections. Renal function improved with withdrawal of this agent and without the requirement of corticosteroids. All new medication changes should be held in suspicion as a cause of acute onset abnormalities in serum biochemistry.
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