One of the most frequent hereditary causes of thrombophilia is, without a doubt, resistance to Activated Protein C (APC-resistance), which is a consequence of point mutation in gene coding for coagulation Factor V (Factor V Leiden) in - of cases. Th e aim of this paper was to determine prevalence of APC-resistance in a group of healthy blood donors. Th e size of the group is quite representative of Kosovo Albanians. A total of blood donors were examined ( males and females), for whom APC-resistance was determined by functional methods of coagulation using the kit ACTICLOT® Protein C Resistance. Method is based on the test of APTT determined twice: fi rst in the presence and second in the absence of activated Protein C (APC). Th e ratio of these two values constitutes is called Activated Protein C -Sensitivity Ratio (APC-SR). From examined donors, pathologic values of APC-SR (,-,) were found in persons (, of the total number). Th e distribution among sexes was , (/) in male and , (/) in female subjects. Th e mean values of APC-SR (, in male and , in female subjects) were not signifi cantly diff erent (P = ,). Based on these results, we conclude that the prevalence of APC resistance in Albanian population of Kosovo is within the lower limit of prevalence in general population in diff erent countries of European countries, which, according to some authors ranges is from to .
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