Cabergoline, a new prolactin inhibitor, was evaluated clinically in 143 bitches with pseudopregnancy and, or, false lactation, 14 cases of lactation after ovariohysterectomy for the removal of dead fetuses, 12 cases of persisting lactation after early weaning, and five cases of eclampsia. The drug was administered as a once‐daily oral treatment (on food) in 139 cases or as subcutaneous injections at 48 hour intervals (maximum four injections) at a dose of 5, 2–5 or 1–5 μg/kg bodyweight in 35 cases. Improvement was evident within three to four days, and in 80 per cent of the cases clinical signs (abnormal behaviour, mammary gland swelling. milk secretion) had been significantly reduced or had disappeared within seven days. Treatment was successful in 95 per cent of the cases. Emesis was the only objectionable clinical side effect, being seen in 3 per cent of orally treated animals and necessitated withdrawal of one dog from the study. Vomiting occurred after the first (65‐7 per cent) and second (22‐9 per cent) injection only.

A potent anti-prolactin drug, cabergoline, administered orally for five days, was clinically successful in treating three different clinical manifestations of pseudopregnancy in referred bitches. The clinical conditions treated were categorised as standard pseudopregnant bitches (n = 8), those previously unsuccessfully treated with hormones (n = 10) and those which had behavioural pseudopregnancy following ovariohysterectomy (n = 8). The number of bitches whose owners reported a 'good' response was seven out of eight, six out of 10 and six out of eight, respectively. There were very few side effects in that only one bitch vomited following treatment. The clinical response did not necessarily appear to be related to an alteration in circulating prolactin concentrations, suggesting that the drug may have a direct effect on the tissues as well as in most cases reducing the plasma prolactin concentrations.

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Contents: I n this study the amount o f milk produced during the first week o f lactation was compared in sows with induced parturition and sows which delivered spontaneously (with special attention to sows showing M M A symptoms). Fifteen sows ( L X LW) were used f r o m a pig farm in which M M A was seen in 20 t o 25% o f all farrowings. The animals were divided into three groups o f 5 each. Group A and B were treated with two different PGFz(w analogs (2 m g o f alfaprostol or 0.45 m g o f tiaprost) o n 111 day of pregnancy, and group C (control) with 2 m l o f saline solution. Treatment with PGF analogs induced parturitions 24 t o 30 h later, controls delivered spontaneously on day 114. Litters were equalized to nine piglets per sow. The milk yield o f each sow was calculate using the method o f weighingpiglets before and after each suckling. Piglets were allowed t o suckle 12 times in the first 24 h after parturition, then 8 or 9 times in the n e x t 24 h and f r o m 48 h onwards 8 times during 24 h, until the end o f the 7 day observation period. During the first day afterparturition the control group appeared t o produce slightly more milk than groups A and B whereas f r o m 24 t o 48 h, milk yields decreased in all animals. From 48 onwards milk production increased in all groups. Between 72-96 h, t w o sows o f the control group showed s y m p t o m s o f M M A and their piglets developed diarrhea. Microbiological analysis confirmed the presence o f haemolytic Streptococci. The lactation curves o f treated and untreated sows with no signs o f M M A were very similar; the pattern was more erratic in sows with MMA. The total milk yields during the first week o f lactation did n o t differ between groups; there were n o significative difference in the weight gain of the piglets in groups A , B and C. The difference recorded in milk yield and release patterns between sows with or without M M A opens new aspects with regard t o the aetiology o f a syndrome that n o t only involves the sows health, but produces intestinals disease in their piglets. Inhalt: Milchleistung von Sauen nach spontaner Geburt und nach Geburtsauslosung durch PGFz Cv-Analoge Die Milchproduktion von Sauen wurde wahrend der ersten Woche post partum nach spontaner oder mit PGF-Analogen induzierter Geburt bestimmt, unter besonderer Beriicksichtigungvon Anzeichen des M M A Syndroms. Fiinfzehn Kreuzungssauen ( L x L W ) aus einer Herde mit einer M M A Haufigkeit von 20 bis 25% wurden in diesen VersuchResearch Supported in part (40%) by MPI U.S. Copyright Clearance Center Statement: 0044-5371/86/2101-0008 $ 02.50/0 Milk Production in Sows after Spontaneous Delivery . . . 9 genommen. Bei je 5 Sauen wurde die Geburt a m I l l . Tag der Graviditat m i t entweder 2 mg Alfaprostol (Gruppe A ) oder 0.45 m g Tiaprost (Gruppe B ) induziert; fiinf Kontrollsauen erhielten 2 m l Kochsalzlosung und ferkelten spontan a m 114. Tag. Alle Tiere der Gruppen A u n d B ferkelten 24 bis 30 Std. nach der Behandlung. Die Wiirfe wurden auf 9 Ferkel egalisiert. Milchle...

This study was conducted in order to evaluate effects on prolactin (PRL) concentration and mammary milk secretion of an injectable cabergoline formulation administered to five lactating Beagle bitches during early postpartum (PP). Bitches were bled twice daily (from PP day 3 to PP day 12) and then daily (from PP day 13 to PP day 16) to assay serum PRL. On PP day 6, a subcutaneous (SC) injection of 0.1 ml/kg of placebo was administered. On PP day 9, a SC 0.1 ml/kg dose of injectable cabergoline was administered. All bitches were checked for milk production, using a clinical scoring in order to quantify milk expression from each teat. A circadian variation of serum PRL was evident during the 6 days of pre-treatment monitoring. The day after cabergoline injection, an 80% decrease of PRL serum concentration was observed (p < 0.05). The circadian oscillatory pattern of PRL secretion disappeared after administration of cabergoline, and PRL values remained significantly lower than in the previous days for the first 60 h following treatment (p < 0.001). Milk production was drastically reduced when comparing pre-treatment to post-treatment scores (p < 0.001). A single dose of injectable cabergoline caused a significant reduction in serum PRL concentration and a significant reduction in milk flow. The injectable formulation of cabergoline appeared to be safe and well tolerated.