Unlike the sulphonamides, which soon after therapeutic birth began to show occasional reactions, penicillin has maintained a relatively uncloaded reputation. Publication of the following case is therefore of interest. Case HistoryOn Sept. 7, while reconnoitring an enemy-held wood, a tank squadron commander was hit by a fragment of an 88-mm. shell which traversed his tank. The fragment-1l by 1 cm.-which was embedded superficially in his lower lateral right calf, was removed an hour later and a sulphanilamide dressing applied. The officer remained on duty, but on Sept. 19 the leg became painful and the ankle swollen. He was admitted to a field dressing station, where sodium sulphate dressings were applied. On Sept. 24 sodium penicillin solfition was instilled direct into the wound, with a similar application on the following day. On Oct. 2 he was admitted to a casualty clearing station, where a sinus-1 in. long was opened up. Since this officer was a key man urgently required by his unit, undiluted sodium penicillin powder (without sulphonamide vehicle) was applied in a much higher concentration than-is normally employed, in the hope that recovery might be hastened. Similar application was made on Oct. 5. Progress was satisfactory, and on Oct. 10 the wound bad almost completely epithelized. On Oct. 11 the patient intimated that he had a mild chronic bilateral external otitis. At 5 p.m. the same day two drops of sodium penicillin solution (100,000 units in 5 c.cm.) were instilled with a pipette into each ear. By 2 a.m. the next morning both ears were discharging profusely. His leg, previously almost healed, began to weep copiously, and literally saturated a moderately heavy cottonwool dressing. The area affected

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