A 'cardio-geriatric' heart failure model of care was implemented to address the high rates of readmission in elderly acute decompensated heart failure patients. Despite demonstrably intensified management in both the cardiology and geriatric domains, this study did not demonstrate a positive effect on the primary outcome of all cause readmissions at 30 days.
was analysed using multiway ANOVAs and post-hoc Tukey HSDs. Results: Left ventricular develop pressure measurements taken post-ischaemia (LVDP%) revealed that IPCs (82.9±2.53%) were protected against LTI-35m (NPC: 57.5±5.62%) (P<0.05). LVPD% recovery was reduced in (+)-naltrexone-IPC (68.3±4.13%) and (+)-naloxone-IPC (71.1±3.96%) groups compared to IPCs (P<0.05). Neither drugs affected the LVDP recovery in NPC hearts (P>0.05). A conditioning and treatment effect was observed (P<0.05) in hearts treated with (+)-naloxone, but not (+)-naltrexone, when cytosolic C-FABP & HMGB1 was examined. No significance in Il-1 was observed between groups. Conclusion: (+)-Naltrexone & (+)-naloxone at 20 M blocks early LVDP recovery after ischaemia. (+)-naloxone alters cytosolic C-FABP and HMGB1 levels.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.