A ‘Cardiogeriatric Model’ of Care in Acute Decompensated Heart Failure: Implementation of a Multidisciplinary Approach, Impacting 30-Day Hospital Readmission

Abstract

was analysed using multiway ANOVAs and post-hoc Tukey HSDs. Results: Left ventricular develop pressure measurements taken post-ischaemia (LVDP%) revealed that IPCs (82.9±2.53%) were protected against LTI-35m (NPC: 57.5±5.62%) (P<0.05). LVPD% recovery was reduced in (+)-naltrexone-IPC (68.3±4.13%) and (+)-naloxone-IPC (71.1±3.96%) groups compared to IPCs (P<0.05). Neither drugs affected the LVDP recovery in NPC hearts (P>0.05). A conditioning and treatment effect was observed (P<0.05) in hearts treated with (+)-naloxone, but not (+)-naltrexone, when cytosolic C-FABP & HMGB1 was examined. No significance in Il-1␤ was observed between groups. Conclusion: (+)-Naltrexone & (+)-naloxone at 20 M blocks early LVDP recovery after ischaemia. (+)-naloxone alters cytosolic C-FABP and HMGB1 levels.