Sulphamethaxazole is antibiotic used to treat several types of bacterial infections and gives double effect when used with trimethoprim by 1 to 5 of sulphamethaxazole. It has a broad spectrum effect on the positive and negative bacteria of Gram and fungi. The objective of this research is to convert sulfamethasazole to nano sulfamethasazole by Sol-gel method by using additive material like acetic acid, distilled water and ethanol with temperature 80°C and probe sonicator machine as catalyst and hydrolysis factor. Nano sulphamethoxazole solution analyzed by atomic force microscope (AFM) was show average of nano particles at size (50±10) nm. Scanned by TEM and SEM shows nano particles as a band of hollow tubes with a diameter less than 100 nm., beside the EDS pattern show high peaks of sodium, carbon and oxygen along with some other constituents. The antibacterial activity of nano solution shows respectable inhibition activity compared to slandered solution.
Aims: This study aims to investigate the inhibitory susceptibility of extract Sidr leaf (Ziziphus spina-christi) aqueous, silver nanoparticles Ag NPs and Sidr nanoparticle "Nano-sidr" (Ziziphus spina-christi) against local isolates of Staphylococcus.SPP, and their inhibition effect on biofilm formation. Study Design: Initially diagnosed by The use of Mannitol salt agar medium, then 26 isolates were selected from them depending on the resistance to methicilln and Vancomycin that were conducted. Place and Duration of Study: The samples were collected from AL-Najaf AL-Ashraf and Baghdad hospitals. Methodology: These isolates were subjected to a VITEK-2 compact system "ID, AST", to ascertain the genus and type of Staphylococcus bacteria., morphological and biochemical tests were conducted on them to confirm them. Results: The result of the diagnosis showed 10 isolates belonging to Staphylococcus aureus, and a number of them were resistant to as MRSA-VRSA, and 7 were Staphylococcus haemolyticus and they were all resistant and known as MRSA-VRSA, and two isolates of Staphylococcus sciuri bacteria, one of them was resistant to VRSA and the other to MRSA-VRSA , two isolates of Staphylococcus warneri were both resistant to MRSA, two isolates of Staphylococcus lugdunensis were resistant to antibiotics, one of them was VRSA and the other was MRSA-VRSA, and one isolate of Staphylococcus lentus was also resistant to antibiotics MRSA-VRSA, and one isolate of Staphylococcus warneri was resistant to MRSA-VRSA, and one isolate of Staphylococcus lugdunensis was resistant to antibiotics. Conclusion: Isolation of Staphylococcus vitulinus. 11 different isolates were selected from them according to their resistance to antibiotics, and after selecting the most efficient one by examining the inhibitory activity by diffusion method. The results showed the ability of both types of nanoparticles. Plant extracts prevent the formation of biofilms
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.