In this study, a biodegradable thermo-sensitive hydrogel from poly(trimethylene carbonate)15-F127-poly(trimethylene carbonate)15 (PTMC15-F127-PTMC15) was designed and evaluated as an injectable implant during ocular glaucoma filtration surgery in vivo and in vitro. Mitomycin C (MMC) was loaded into this hydrogel for controlled released to prolong the efficacy and to reduce the long-term toxicity. The properties of the hydrogel were confirmed using 1H NMR and gel permeation chromatography (GPC). Compared to the Pluronic F127 hydrogel, the PTMC15-F127-PTMC15 hydrogel showed a good solution-gel transition temperature at 37°C, a lower work concentration of 5% w/v and a longer mass loss time of more than 2 weeks. The in vitro study showed that the drug could be released from PTMC15-F127-PTMC15 (5% w/v) hydrogel for up to 16 days with only 57% of drug released in the first day. Moreover, the cell toxicity, which was tested via LDH and ANNEXIN V/PI, decreased within 72 h in human tenon's fibroblast cells (HTFs). The in vivo behavior in a rabbit glaucoma filtration surgery model indicated that this hydrogel loaded with 0.1 mg/ml MMC led to a better functional bleb with a prolonged mean bleb survival time (25.5±2.9 days). The scar tissue formation, new collagen deposition and myofibroblast generation appeared to be reduced upon histological and immunohistochemistry examinations, with no obvious side effects and inflammatory reactions. The in vitro and in vivo results demonstrated that this novel hydrogel is a safe and effective drug delivery candidate in ocular glaucoma surgery.
Purpose : This study aims to know the seeking help behavior (including seeking help or not, first choice, influential factors and barriers in seeking help) of individuals with SZ in Hunan province of China. Methods : The participants are from a larger epidemiological study of severe mental disorders in Hunan province of China. Self-made questionnaires were used to collect relative information. Results : 1) Of the 367 participants, 68.9% (253/367) sought help; of those, 64.6% (n=163) pursued professional psychiatric services and 30.8% (n=78) pursued non-medical options (i.e., relatives, praying to Buddha) as the most common first choices. 2) The help-seeking behavior ratio (seeking help individuals/total sample size) is significantly lower in the illiterate group than in other education levels. Those with a family history of mental disorders tend to have a higher help-seeking behavior ratio. And the first choice of help is largely related to education level. 3) Frequent reasons behind not seeking help include fear of stigmatization (72.9%), poor mental health literacy (64.5%), concerns over cost (50.6%), and limited access to medical services (47.0%). Conclusion : About one third of the individuals do not seek help. Individuals with SZ tend to choose psychiatric hospital and relatives as their first choice. A family history of mental disorders and higher education levels are meaningfully associated with help-seeking behavior, and individuals with more education tend to seek for professional help first. The primary reasons for not seeking help include fear of stigmatization, lack of awareness about mental illness, concerns over cost, etc.
PurposeThis study aims to know the seeking help behavior of individuals with SZ (Schizophrenia) in Hunan province of China. MethodsThe participants are from a larger epidemiological study of severe mental disorders in Hunan province of China. Self-made questionnaires were used to collect relative information. Results1) Of the 367 participants, 68.9% (253/367) sought help; of those, 64.6% (n=163) pursued professional psychiatric services and 30.8% (n=78) pursued non-medical options (i.e., relatives, praying to Buddha) as the most common first choices. 2) The help-seeking behavior ratio is significantly lower in the illiterate group than in other education levels. Those with a family history of mental disorders tend to have a higher help-seeking behavior ratio. 3) Frequent reasons behind not seeking help include fear of stigmatization (72.9%), poor mental health literacy (64.5%), concerns over cost (50.6%), and limited access to medical services(47.0%).ConclusionAbout one third of the individuals do not seek help. Individuals with SZ tend to choose psychiatric hospital and relatives as their first choice. A family history of mental disorders and higher education levels are meaningfully associated with help-seeking behavior, and individuals with more education tend to seek for professional help first. The primary reasons for not seeking help include fear of stigmatization, lack of awareness about mental illness, concerns over cost, etc.
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