Synthesis and controlled release of mitomycin C from a chitosan-based polymeric prodrug

Duan, Li; Zheng, Qiongjuan; Li, Xiaoning; Ge, Jian

doi:10.1016/j.jconrel.2011.08.096

Cited by 6 publications

(6 citation statements)

References 3 publications

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“…This has been examined in the animal models of bone injury repair, skin wound repair, and prevention of cardiac fibrosis after myocardial infarction (MI) and cancer treatment. 116,117 Hydrogels, similar to the ECM, are three-dimensional (3D) networks comprising hydrophilic polymer chains that are physically or chemically cross-linked to absorb water. 118 Hydrogel systems have been widely applied in drug delivery and regenerative medicine because of their biodegradability, injectability, and biocompatibility.…”

Section: Extracellular Vesicle Delivery Strategies In Liver Diseases ...mentioning

confidence: 99%

Native and engineered extracellular vesicles: novel tools for treating liver disease

Jiang,

Tian,

Wang

et al. 2024

J. Mater. Chem. B

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Section: Extracellular Vesicle Delivery Strategies In Liver Diseases ...mentioning

confidence: 99%

Native and engineered extracellular vesicles: novel tools for treating liver disease

Jiang,

Tian,

Wang

et al. 2024

J. Mater. Chem. B

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“…That is possible to deal with the application of chitosan as a carrier for water-insoluble and water-soluble drug conjugates in anti-scarring therapy. Izume summarized the toxicity of chitosan including a skin sensitization study, temporal skin irritation study, ophthalmic sensitization test, mutagenicity test and patch test for humans; every study and test showed low toxicity of chitosan, which can function well as a drug carrier due to long systemic retention, low toxicity and accumulation in the target tissue[ 24 - 26 ].…”

Section: Presentation Of Hypothesismentioning

confidence: 99%

“…When the m CS-CHO / m MMC was 5/1, 10/1 and 25/1, the initial release amount of MMC was 65%, 50% and 45%. There was an obvious initial release within the initial 8 h, and the concentration of MMC in dialysis medium remained unchanged during the following 60 h. Furthermore, the cytotoxicity study on chitosan-based polymeric predrug encapsulated fibroblast indicated that the maximum non-toxic concentration of CS-CHO was 8.3, 42.3 and 54.7 mg/ml in the 24, 48 and 72 h[ 26 ]. Therefore, the concentration of CS-CHO in the practical application should be lower than the corresponding concentration.…”

Section: Testing the Hypothesismentioning

confidence: 99%

Target drug delivery system as a new scarring modulation after glaucoma filtration surgery

Shao

2011

Diagn Pathol

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BackgroundExcessive wound healing following glaucoma filtration surgery is the main determinant of surgical failure, resulting from the activation of human Tenon's capsule fibroblasts (HTFs). To mitigate the excessive wound healing, the topicall use of antiproliferative agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), has increased the surgery success rate, but the traditional administration of these agents can result in a variety of toxicities with nonspecific damage. However, modulation of the wound healing process to prevent excessive fibroblast proliferation and scar formation can play a major role in improving the outcome of surgery. Therefore, the search for alternative modes of drug delivery and new agents is needed to minimize the ocular complications and improve the success of surgery. We have shown that there is a postoperative overexpression of the LDL receptor (LDLr) in the activated HTFs may provide a novel target for drug delivery systems.Presentation of the HypothesisWe hypothesize that antifibrotic agents (MMC) encapsulated in LDLr targeting drug delivery system (LDL-MMC-chitosan nanoparticles) may be proposed in anti-scarring therapy to increase the safety and effectiveness and to reduce toxicity.Testing the HypothesisA chitosan-based polymeric predrug of MMC was synthesized and its cytotoxicity was proved to be low. In addition, we propose hyaluronic acid film as a container to release LDL-MMC-chitosan nanoparticles gradually at subconjunctival filtering site after glaucoma filtration surgery to eliminate the LDL-MMC-chitosan nanoparticles.Implications of the Hypothesis and discussionThis strategy can be applicable to anti-scarring therapy during excessive conjunctival wound healing. This hypothesis integrates advantages of the targeting drug delivery and antifibrotic agents, such as high efficiency, convenience, and lower the toxicity.

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“…Moreover, the polymeric prodrug with abundant active groups can be further functionalized . Lastly, the decelerated hydrolysis and enzymolysis due to stereo‐specific blockade allows the active cargo to gradually fall off from the polymer backbone, thus realizing sustained drug release .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Optimization of a Bifunctional Hyaluronan‐Based Camptothecin Prodrug

Zheng

Yin

2014

Archiv der Pharmazie

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Aiming to overcome the low solubility and poor targeting ability of camptothecin (CPT), two hyaluronan (HA)-based polymeric prodrugs with different molecular weights (MW) were synthesized and characterized. The structure of HA-CPT was thoroughly verified by ultraviolet (UV), infrared (IR), (1)H nuclear magnetic resonance ((1)H NMR), differential scanning calorimetry (DSC), and high performance liquid chromatography (HPLC). The conjugation of CPT to HA successfully improved the solubility of CPT from 2.08 to 420-620 µg/mL and enhanced tumor targeting, as shown by the in vitro uptake and cytotoxicity results. Moreover, it was found that the high MW conjugate exhibited higher drug loading, higher stability but lower solubility compared with the low MW conjugate. Both HA-CPT conjugates exhibited similar uptake efficiency and antitumor activity. The results demonstrated that HA could act as an effective solubilization carrier and targeting molecule in a HA-based CPT prodrug.

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Synthesis and controlled release of mitomycin C from a chitosan-based polymeric prodrug

Cited by 6 publications

References 3 publications

Native and engineered extracellular vesicles: novel tools for treating liver disease

Native and engineered extracellular vesicles: novel tools for treating liver disease

Target drug delivery system as a new scarring modulation after glaucoma filtration surgery

Synthesis and Optimization of a Bifunctional Hyaluronan‐Based Camptothecin Prodrug

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