River-tide dynamics remain poorly understood, in part because conventional harmonic analysis (HA) does not cope effectively with nonstationary signals. To explore nonstationary behavior of river tides and the modulation effects of river discharge, this work analyzes tidal signals in the Yangtze River estuary using both HA in a nonstationary mode and continuous wavelet transforms (CWT). The Yangtze is an excellent natural laboratory to analyze river tides because of its high and variable flow, its length, and the fact that there are do dams or reflecting barriers within the tidal part of the system. Analysis of tidal frequencies by CWT and analysis of subtidal water level and tidal ranges reveal a broad range of subtidal variations over fortnightly, monthly, semiannual, and annual frequencies driven by subtidal variations in friction and by variable river discharges. We employ HA in a nonstationary mode (NSHA) by segregating data within defined flow ranges into separate analyses. NSHA quantifies the decay of the principal tides and the modulation of M 4 tide with increasing river discharges. M 4 amplitudes decrease far upriver (landward portion of the estuary) and conversely increase close to the ocean as river discharge increases. The fortnightly frequencies reach an amplitude maximum upriver of that for over tide frequencies, due to the longer wavelength of the fortnightly constituents. These methods and findings should be applicable to large tidal rivers globally and have broad implications regarding management of navigation channels and ecosystems in tidal rivers.

Numerous research efforts have been devoted to understanding estuarine morphodynamics under tidal forcing. However, the impact of river discharge on estuarine morphodynamics is insufficiently examined. Inspired by the Yangtze Estuary, this work explores the morphodynamic impact of river discharge in a 560 km long tidal basin based on a 1-D model (Delft3D). The model considers total load sediment transport and employs a morphodynamic updating scheme to achieve long-term morphodynamic evolution. We analyze the role of Stokes drift, tidal asymmetry, and river discharge in generating tidal residual sediment transport. Model results suggest that morphodynamic equilibrium is approached within millennia by vanishing spatial gradients of tidal residual sediment transport. We find that the interaction between ebb-directed Stokes return flow/river flow with tides is an important mechanism that flushes river-supplied sediment seaward. Increasing river discharge does not induce continuously eroded or accreted equilibrium bed profiles because of the balance between riverine sediment supply and sediment flushing to the sea. An intermediate threshold river discharge can be defined which leads to a deepest equilibrium bed profile. As a result, the shape (concavity or convexity) of the equilibrium bed profiles will adapt with the magnitude of river discharge. Overall, this study reveals the significant role of river discharge in controlling estuarine morphodynamics by supplying sediment and reinforcing ebb-directed residual sediment transport.

Urban pluvial flood are attracting growing public concern due to rising intense precipitation and increasing consequences. Accurate risk assessment is critical to an efficient urban pluvial flood management, particularly in transportation sector. This paper describes an integrated methodology, which initially makes use of high resolution 2D inundation modeling and flood depth-dependent measure to evaluate the potential impact and risk of pluvial flash flood on road network in the city center of Shanghai, China. Intensity-Duration-Frequency relationships of Shanghai rainstorm and Chicago Design Storm are combined to generate ensemble rainfall scenarios. A hydrodynamic model (FloodMap-HydroInundation2D) is used to simulate overland flow and flood inundation for each scenario. Furthermore, road impact and risk assessment are respectively conducted by a new proposed algorithm and proxy. Results suggest that the flood response is a function of spatio-temporal distribution of precipitation and local characteristics (i.e. drainage and topography), and pluvial flash flood is found to lead to proportionate but nonlinear impact on intra-urban road inundation risk. The approach tested here would provide more detailed flood information for smart management of urban street network and may be applied to other big cities where road flood risk is evolving in the context of climate change and urbanization.

Superoxide is the proximal reactive oxygen species (ROS) produced by the mitochondrial respiratory chain and plays a major role in pathological oxidative stress and redox signaling. While there are tools to detect or decrease mitochondrial superoxide, none can rapidly and specifically increase superoxide production within the mitochondrial matrix. This lack impedes progress, making it challenging to assess accurately the roles of mitochondrial superoxide in cells and in vivo. To address this unmet need, we synthesized and characterized a mitochondria-targeted redox cycler, MitoParaquat (MitoPQ) that comprises a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat. MitoPQ accumulates selectively in the mitochondrial matrix driven by the membrane potential. Within the matrix, MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ increased mitochondrial superoxide in isolated mitochondria and cells in culture ~a thousand-fold more effectively than untargeted paraquat. MitoPQ was also more toxic than paraquat in the isolated perfused heart and in Drosophila in vivo. MitoPQ enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.

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Morphodynamic equilibrium is a widely adopted yet elusive concept in the in the setting) so that the concept of morphodynamic equilibrium should be 13 * Corresponding

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