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This study linked emotion to the theoretical assumptions of the face‐negotiation theory and probed the critical role of anger, compassion, and guilt in understanding the complex pathways of their relationships with self‐construal, face concerns, and conflict styles in U.S. and Chinese cultures. Results showed that anger was associated positively with independent self‐construal, self‐face concern, and the competing style, and compassion was associated positively with interdependent self‐construal, other‐face concern, and the integrating, compromising, and obliging styles. Guilt was related positively with interdependent self‐construal and the obliging style in the United States, and with interdependent self‐construal and the avoiding style in China. Overall, emotion mediated the effects of self‐construal and face concerns on conflict styles in both cultures, but cultural differences also emerged.

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Malignant glioma is a formidable disease that commonly leads to death, mainly due to the invasion of tumor cells into neighboring tissues. Therefore, inhibition of tumor cell invasion may provide an effective therapy for malignant glioma. Here we report that nicotinic acid (NA), an essential vitamin, inhibits glioma cell invasion in vitro and in vivo. Treatment of the U251 glioma cells with NA in vitro results in reduced invasion, which is accompanied by a loss of mesenchymal phenotype and an increase in cell-cell adhesion. At the molecular level, transcription of the adherens junction protein E-cadherin is upregulated, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to NA’s ability to facilitate the ubiquitination and degradation of Snail1, a transcription factor that represses E-cadherin expression. Similarly, NA transiently inhibits neural crest migration in Xenopus embryos in a Snail1-dependent manner, indicating that the mechanism of action for NA in cell migration is evolutionarily conserved. We further show that NA injection blocks the infiltration of tumor cells into the adjacent brain tissues and improves animal survival in a rat model of glioma. These results suggest that NA treatment may be developed into a potential therapy for malignant glioma.