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The relationship between survival and time to the start of adjuvant chemotherapy (AC) among breast cancer patients is unclear. In order to illustrate the effect of delaying the initiation of AC on survival we have undertaken a systematic review and meta-analysis.We identified 12 available studies in the meta-analysis including 15 independent analytical groups. This meta-analysis showed that a 4-week delay before AC was associated with a significantly worse overall survival (OS)(HR=1.13; 95% confidence interval [CI], 1.08–1.19) and disease free survival (DFS)(HR=1.14; 95%CI, 1.05–1.24). Two studies categorized patients into hormone receptor-positive, ERBB2-positive, and triple-negative breast cancer (TNBC) patients according to the clinicopathological features of breast cancer. The HRs for OS between waiting time (WT) ≤30 days and 31–60 days in the subgroups were extracted and analyzed. The analysis demonstrated that a WT of 31–60 days was related to worse OS among patients with TNBC (HR, 1.26; 95% CI, 1.08–1.48), but had no significant effect on OS among those with hormone receptor-positive (HR, 1.02; 95% CI, 0.89–1.15) or ERBB2-postive (HR, 0.95; 95%CI, 0.79–1.14) tumors.In this meta-analysis of the eligible literatures reviewing the time to AC, a longer waiting time to adjuvant chemotherapy may lead to worse survival in breast cancer patients, especially in TNBC patients.

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Articles you may be interested inElemental and isotopic analysis of inorganic salts by laser desorption ionization mass spectrometry AIP Conf.A high resolution dual mass gate for ion separation in laser desorption/ionization time of flight mass spectrometry Rev.Ultrasensitive fingerprint detection of organometallic compounds by laser multiphoton ionization mass spectrometry Appl. Phys. Lett. 45, 1175Lett. 45, (1984; 10.1063/1.95082Laser ionization mass spectrometry: Extensive fragmentation via resonanceenhanced multiphoton ionization of a molecular benzene beam

A novel interface has been developed which should allow the direct on-line coupling of liquid capillary chromatography with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry detection. The interface employs continuous analyte/matrix co-crystallization onto a porous frit installed at a capillary end which is used as the target for MALDI. After separation, the analyte effluent is premixed with the MALDI matrix solution and introduced into the interface. The analyte/matrix mixture is co-crystallized onto the frit surface in the vacuum environment of the mass spectrometer. Continuous matrix/analyte crystallization and interface regeneration is accomplished by a combination of solvent flushing and laser ablation. The memory effect is negligible over a dynamic range of ca. 200. Several applications, including analysis of small peptides and combination with gel permeation chromatography (GPC), have indicated that the on-line MALDI interface does not sacrifice chromatographic or mass spectral resolution, and have demonstrated the possibility of a reliable LC-MALDI system. Copyright 1999 John Wiley & Sons, Ltd.

Two-step laser mass spectrometry (LZMS) was applied to study the chemical nature of adsorbates on aerosol particles which were collected from different sites, e.g. in the countryside, in an industrial zone, by a downtown road, and in a tunnel. The method combines infrared laser desorption from the particle surfaces followed by ultraviolet laser post-ionization of the desorbed neutral molecules. Because of the high sensitivity and optical selectivity of LZMS, virtually no sample preparation is needed, and mass spectra can be recorded in a very short time. Qualitative and quantitative comparisons of plycyclic aromatic hydrocarbons in different sampling areas were carried out. By scanning the ionization laser wavelength, two-dimensional UV/MS spectra can be generated for better identification of the adsorbed species.

Two-step laser mass spectrometry has been employed for the direct in-situ analysis of a variety of additives in different polymers. Because of the high sensitivity and optical selectivity of this approach, mass spectra can be obtained directly from the polymer material. The effects of CO2 laser irradiation (λ = 10.6 μm) on samples of poly(oxymethylene) (POM), poly(vinyl chloride) (PVC), polypropylene (PP), and poly(ethylene terephthalate) (PET) and the mechanism of additive desorption have been examined. Several hydroxyphenylbenzotriazole (Tinuvin) UV stabilizers as well as a phenolic antioxidant (Santo White) were successfully detected in typical industrial polymers. The detection limit for Santo White antioxidant in POM was found to be as low as 28 ppm. Finally, depth profiling by stepwise CO2 laser ablation was carried out for a POM injection bar containing 0.1 wt % antioxidant. These spatially resolved measurements established that the near surface concentration of antioxidant was 40% lower than in the bulk.

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