Latar belakang: Sejak diumumkan pertama kali pada Desember 2019, jumlah penderita COVID-19 terus meningkat. Seiring dengan perkembangan penyakit ini yang begitu pesat, berbagai masalah pun mulai bermunculan. Serial kasus ini ditulis untuk mengangkat pengalaman dalam penanganan pasien keganasan dalam keterbatasannya pada masa pandemi COVID-19. Kasus: Pertama, pasien peripheral T-cell lymphoma yang sudah kemoterapi CHOP 4 siklus di Singapura dan akan melanjutkan siklus selanjutnya bulan April 2020. Kedua, pasien dengan pleomorphic spindle cell sarcoma regio toraks posterior metastasis ke paru dan tulang sudah mendapatkan kemoterapi lini kedua dengan regimen Gemcitabine/Docetaxel di Singapura, dan akan melanjutkan kemoterapi selanjutnya akhir Maret 2020, akan tetapi pasien mengalami neutropenia dan menolak ke rumah sakit untuk injeksi karena takut. Ketiga, pasien dengan karsinoma payudara Her-2 type yang sedang menjalani terapi target Kadcyla di London. Pasien pertama dan ketiga tidak dapat melanjutkan terapi di luar negeri karena pandemi COVID-19. Simpulan: Pandemi COVID-19 secara langsung menyebabkan perubahan besar dalam layanan rumah sakit. Penundaan pengobatan pada pasien kanker yang dapat dilakukan atau melanjutkan pengobatan dengan peningkatan kewaspadaan akan transmisi COVID-19 merupakan opsi yang dapat dilakukan dan dipertimbangkan secara matang oleh klinisi.
BACKGROUND: Breast cancer tends to respond differently to treatments, which are usually determined by clinicopathological characteristics. Several studies evaluated the role of the peripheral blood test as diagnostic and prognostic markers in several types of solid cancer and neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) are two of them which already tested. However, the evidence in breast cancer is still lacking.
AIM: Therefore, the study aimed to investigate the value of NLR and PLR as biomarkers concerning breast cancer stage.
METHODS: A retrospective study was conducted using breast cancer patients’ medical records from 2014 to 2019 at Sanglah General Hospital. The histopathological records and complete blood counts of the patients were collected and analyzed risk analysis model, receiver operator characteristics analysis, and correlation of NLR and PLR with cancer staging analysis used correlation test.
RESULT: One hundred five patients data were used in this study, with 35 subjects had early-stage breast cancer while 70 subjects had an advanced stage. Breast cancer staging with NLR and PLR showed significant associations (p < 0.001). Both NLR and PLR had area under the curve >0.7 (p < 0.001). The cutoff, sensitivity, and specificity values of NLR and PLR were 2.504 (71%; 70%) and 157.1 (73%; 70%). Advanced stage of breast cancer was mostly found in high NLR and PLR value with (OR: 4.231; CI = 1.791-9.995, p < 0.001) and (OR: 3.949; 95% CI = 1.679–9.287; p < 0.001).
CONCLUSION: From this preliminary study, pretreatment NLR and PLR values might determine the breast cancer stage. Further research is needed to evaluate the association between grade and patient survival.
Background: Malignant melanoma (MM) is one of the skin malignancies derived from melanocyte cells. It is the most common cause of death, about 75% of all cases of skin cancer. Skin cancer is ranked fourth among the ten most common tumors in Bali. Aim: To know the characteristics of malignant melanoma patients in the subsection of surgical oncology Sanglah Hospital Year 2015-2016. Method: This study is cross-sectional descriptive research conducted at Sanglah General Hospital in Denpasar. The data obtained in the form of secondary data, patient medical records, as of 2015 till 2016. Data were analyzed using the SPSS program. Result and Conclusion: The results showed that of 11 patients, incidence with the highest proportion of patients with age range 45-59 years number of 4 people (36.3%). The most top gender was women of 6 (54.5%). The highest subtype of Nodular Melanoma (NM) was 7 (63.6%).
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