Naringenin is a flavonoid which has been used for its wide pharmacological action from ancient years including as antidiabetic agent. Naringenin is a lipophilic drug (BCS-II) and have low water solubility (1 in 1000), bioavailability (<25%) and have short half-life (t 1/2 =1.3 -2.2h).Nanocrystals is an approach to increase the therapeutic performance of poorly water soluble drugs.The purpose of the present study was to prepare nanocrystalss of naringenin to improve bioavailability and increase therapeutic efficacy. Nanocrystalss of naringenin were prepared by antisolvent precipitation method. The stabilizers used to improve aggregation and increase the solubility. Nanocrystals were characterized for particle size, morphology, release profile and thermal analysis.
In present work, comparative study of sorption potential of raw and chemically activated orange peel powder has been explored for the removal of arsenite ions (As III) from wastewater. Several operating parameters such as contact time, adsorbent dose, adsorbate ion concentration, solution pH as well as temperature were studied in batch reactor. Surface as well as physicochemical analysis of orange peel was done by using FTIR (Fourier Transform Infrared Spectroscopy), SEM (Scanning Electron Microscopy), proximate and ultimate analysis. Maximum removal of As (III) 86.3% and 87% was obtained at initial metal ion concentration 20 mg/l and 25 mg/L, optimum pH 2 and 2.8, temperature 30°C and 25°C, contact time 120 and 150 minutes as well as the adsorbent dose 4g for raw and chemically activated orange peel respectively. Modeling of experimental data showed that Freundlich model (R2 = 97.45) had a better fit over Langmuir isotherm (R2 = 96.33) for raw orange peel and the Freundlich model (R2 =99.8%) in comparison to Langmuir model (R2 =94.5%) shows better fit. The present comparative study depicts that the chemically activated orange peel powder are more effective than raw orange peel powder. Thus, orange peel is found to be promising simple material for removal of arsenite ions (As III) ions.
Abstract:The aim of this study is to prepare and evaluate sericin nanoparticles (NPs) of Verapamil Hcl which are finally formulated as buccal gel. It was envisaged to formulate the nanoparticles with gelatine, sericin and genipin. Nanoparticles incorporated gel was successfully prepared by using carbopol 934. Nanoparticles were prepared by dessolvation followed by crosslinking. Various parameters like drug content, viscosity, pH, spreadability and drug release were used to obtain the optimized formulation. The sericin nanoparticles incorporated gel shows better fast release as compare to API. The obtained results like drug content, % drug release, buccal permeation study confirmed the potential of nanoparticles as good carrier for buccal administration. The optimised sericin nanoparticles range between 100-400 nm with a zeta potential of 29.91mv showing good stability. Later, we proved our hypothesis through In vitro studies for pharmacokinetics, where we found that NPs had better bioavailability than API. NPs showed protective action and maintained normal tissue architecture. We concluded that nanoparticle form of verapamil had better bioavailability and good pharmacological actions, which might be beneficial for future formulation design perspective.
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