Development of Naringenin Nanocrystals for Enhanced Solubility and Bioavailability

Katiyar, Neha; Singhaƒ, Mangla Nand; Yadav, Pushpa; Singh, Haribansh Narayan; Saha, Sudipta; Saraf, Shailendra K.

doi:10.46624/ajptr.2018.v8.i2.008

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…In a study in 2018, NAR nanocrystals with dimensions of 349.2 nm, dispersion index of 0.23, surface charge of 13.86 mV, and rod‐like shape with smooth surface were synthesized. The drug loading efficiency was evaluated indirectly similar to the present study and its rate was reported to be 88.16% 43 . In another study in 2019, chitosan nanoparticles loaded with NRG, with uniform dispersion index, zeta potential of 15.36 mV, and 88‐nm sized were synthesized.…”

Section: Discussionsupporting

confidence: 63%

“…The drug loading efficiency was evaluated indirectly similar to the present study and its rate was reported to be 88.16%. 43 In another study in 2019, chitosan nanoparticles loaded with NRG, with uniform dispersion index, zeta potential of 15.36 mV, and 88-nm sized were synthesized. In this study, the loading rate of NRG was reported greater than 91%.…”

Section: Discussionmentioning

confidence: 99%

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Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

Firouzabadi

Karimi

Tabrizi

2022

Biotech and App Biochem

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Flavonoid compounds play an effective role in cancer suppression and today nanocarriers play an important role in improving the physicochemical properties and transmission of these compounds. In this study, polyethylene glycol‐modified albumin nanoparticles were synthesized by desolvation method; after loading of naringenin (NRG), folic acid (FA) binding to the surface of nanoparticles was performed (BSA–PEG–FA–NG–NPs). The extent of NRG trapping and FA binding was assessed indirectly using UV absorption methods. The physicochemical properties of BSA–PEG–FA–NG–NPs were investigated by DLS, SEM electron microscopy, and FTIR methods, after which their effects were evaluated on the apoptosis mechanism via MTT, flow cytometry, and qPCR methods. The BSA–PEG–FA–NG–NPs with spherical morphology had dimensions of 205 nm with zeta‐potential of 20.61 mV and dispersion index of 0.36. The NRG encapsulation was 84% and the FA binding was 75%. Anticancer effects of BSA–PEG–FA–NG–NPs were confirmed based on inhibiting breast cancer cells (IC50: 922 µg/ml), cell cycle arrest (SubG1 phase), and induction of apoptosis (upregulation of Caspase 3, 8, and 9).

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

Firouzabadi

Karimi

Tabrizi

2022

Biotech and App Biochem

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“…By comparing the absorption intensity of the spectral bands and the content of the chemical groups, it can be observed that the peak positions, peak shapes and trends of the two samples are basically the same (Figure 6), indicating that the properties of the naringenin powder have not changed before and after preparation. Therefore, the spectra before and after the preparation of naringenin have the same vibration frequency, and the chemical structure has no changes [29].…”

Section: Ftir Analysismentioning

confidence: 95%

Naringenin Ultrafine Powder Was Prepared by a New Anti-Solvent Recrystallization Method

et al. 2022

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Raw naringenin directly isolated from plants is significantly limited by its poor dissolution rate and low bioavailability for clinical and in vivo studies. This study reported a method for the preparation of naringenin ultrafine powder (NUP) using a novel anti-solvent recrystallization process; preliminary experiments were conducted using six single-factor experiments. The response surface Box–Behnken (BBD) design was used to optimize the level of factors. The optimal preparation conditions of the DMP were obtained as follows: the feed rate was 40.82 mL/min, the solution concentration was 20.63 mg/mL, and the surfactant ratio was 0.62%. The minimum average particle size was 305.58 ± 0.37 nm in the derived optimum conditions. A scanning electron microscope was used to compare and analyze the appearance and morphology of the powder before and after preparation. The characterization results of FTIR, TG and XRD showed that no chemical change occurred in the powder before and after preparation. Through the simulated gastrointestinal juice digestion experiment, it was confirmed that the absorption rate of NUP was 2.96 times and 4.05 times higher than raw naringenin, respectively. Therefore, the results showed that the reduction in the particle size through the use of low-speed recrystallization could improve the absorption rate and provided a feasible approach for the further applications.

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“…Pharmaceutical research has developed various methods to improve drug solubility, resulting in enhanced bioavailability and therapeutic efficacy at lower dose concentrations. Particle size reduction, solid dispersion, complexation, nanoparticles, liquisolid, microencapsulation, nanosuspension, nanoemulsion, nanocrystal, Self Microemulsion Drug Delivery System (SMEDSS), cocrystal, and coamorphous construction are all methods used to significantly boost the solubility of drugs (Bhardwaj et al, 2016;Katiyar et al, 2018;Kumar & Nanda, 2017;Li et al, 2017;Patel et al, 2018). In recent years more and more methods have been developed to improve the solubility properties of APIs.…”

Section: Introductionmentioning

confidence: 99%

Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study

Reza Pahlevi,

Sopyan,

Gozali

2023

JFG

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Orally active drugs are currently available on the market. API should have adequate solubility and permeability to enhance its therapeutic efficacy when administered orally and obtain optimum bioavailability. Almost 40% of New Chemical Entities had limited solubility or fell into BCS class II and IV. Our review aims to summarize and discuss the development of methods and characterization for increasing the solubility of poorly aqueous drugs from papers published in Google Scholar, NCBI, Science direct, Researchgate, and MDPI. We checked that the methods used such as solid dispersion, cocrystal formation, and coamorphous can increase the solubility of API which has an impact on increasing bioavailability. The successful formation of solid dispersions, cocrystals and coamorphs can be confirmed by the characterization of PXRD, DSC and SEM. In conclusion, drug solubility is an important aspect of pharmacological effects. Drugs with high solubility can provide fast solubility rates and high bioavailability, reducing the dose administered. Solid dispersion, cocrystals, and coamorphous techniques, have succeeded in increasing the solubility of BCS class II and IV drugs.

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Development of Naringenin Nanocrystals for Enhanced Solubility and Bioavailability

Cited by 5 publications

References 10 publications

Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

Fabrication of bovine serum albumin‐polyethylene glycol nanoparticle conjugated‐folic acid loaded‐naringenin as an efficient carrier biomacromolecule for suppression of cancer cells

Naringenin Ultrafine Powder Was Prepared by a New Anti-Solvent Recrystallization Method

Technique Development in Improving the Solubility of Poorly Water Soluble Drugs (BCS II and IV): a Review Study

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