Objectives: The present study assessed the phytochemical components, In vitro antioxidant ability and cytotoxicity of leaf extract of Ficus racemosa. Methods: Preliminary phytochemical analysis in aqueous and ethanol was carried out for the presence of phytochemical components. Of the two extracts used ethanolic extract possessed the highest phytochemical constituents compared to aqueous extract. Hence the antioxidant activity of ethanolic extract of F. racemosa was performed by several antioxidant assays including 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay, nitric oxide (NO) scavenging assay, reducing power and superoxide radical (SO) scavenging assay. Results: From the results, F. racemosa has been found to have the significant antioxidant activity in a dose-dependent manner and IC 50 value was 150 μg/ml for DPPH and 100 μg/ml for both NO and SO scavenging assays. Further, the cytotoxicity analysis was determined against Dalton Lymphoma Ascites (DLA) cell line and the IC 50 value was found to be 175 μg/ml for ethanolic leaf extract of F. racemosa. Conclusion: Hence, the current study attests that F. racemosa is enriched in phytochemicals and a fine source of natural antioxidants with anticancer agents and can be used in pharmaceutical preparations for the treatment of diseases induced by oxidative stress.

Platelets are a prime reason for causing cardiovascular disease (CVD). After atherosclerotic plaque rupture, platelets can form pathogenic, formation of blood clot which leads to various cardiovascular events. The beneficial effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A) reductase inhibitors reduces CVDs clinically. The objective of this review is the pharmacological benefit of atorvastatin in CVD by platelets and plaque rupture due to high levels of cholesterol.

Demans ve felç 65 ya da daha yaşlı bireylerde sıkça görülen büyük bir sağlık problemidir. Kolesterolün demans ve felç patojeninizde yer aldığını doğrulayan pek çok çalışma vardır. Genel olarak koroner kalp hastalığında kolesterolü düşürmek için kullanılan Atorvastatin demans ve felç tehlikesini azaltmada uygulanabilir bir tedavidir. Atrovastatin'in uzun süreli kullanımının demans ve felci önlemede etkili olduğu görünmektedir. Bu çalışmanın amacı demans ve felç durumlarında atorvastatinin farmakolojik yararına odaklanmaktır.