Background Fibroadenoma of breast is the commonest ailment of women with significant morbidity. Available literature revealed that breast tumour recedes by homoeopathic treatment.The present study evaluated the role of homoeopathic treatment on breast fibroadenoma by using ‘Triple assessment criteria’ and to explore the mechanism, whether homoeopathic medicines bring their therapeutic effect by altering the oestrogen and progesterone receptor (ER/PR) status on tumour tissue. Materials and Methods An open label, prospective, single arm, observational study was conducted on 64 female patients having fibroadenoma of breast. Triple assessment criteria were used to explore the effectiveness of homoeopathic treatment on breast fibroadenoma. Individualised homoeopathic medicines were prescribed. The outcome measures were changes in clinical picture, number and size of lump by ultrasonomammography. ER/PR study was performed by immunohistochemistry using quick score analysis. Results Post-treatment response of 23 cases (35.93%) of fibroadenoma revealed disappearance of lump. Partial improvement was noticed in 22 cases (34.37%) with significant reduction in mean size (p < 0.001). Similarly significant reduction in number of lesions was seen in fibroadenoma (p <0.05). Conium maculatum and Phytolacca decandra were found to be the most useful remedies. Quick score value of ER after treatment showed significant reduction (Z = 4.910). Conclusion The study revealed that the therapeutic effects of individualised homoeopathic medicines play significant role in management of fibroadenoma of breast. The results of ER/PR show significant reduction in ER suggesting that homoeopathic medicines have some inhibitory effect on ER.
Background The results of several studies indicated that conventional treatment based on surgery, radiotherapy and chemotherapy is often associated with adverse side effects. Recent studies suggest that patients with cancer (average 31.4%) used complementary therapy at some stage of their illness, and homeopathic medicines might be used to enhance survival and improve quality of life in cancer patients. The aim of this systematic review is to systematically review the literature on homeopathic-controlled clinical studies of adverse effects of radiotherapy and chemotherapy in carcinoma. Methods Substantive research articles, conference proceedings and master and doctoral theses published between 1 January 1981 and 31 December 2018 were eligible. Methodology was assessed by Jadad's scoring, internal validity by Cochrane tool and model validity by Mathie's criteria. Results Eight trials were eligible. Few trials were positive, especially those testing complex formulations. Methodological quality was diverse; five trials had ‘Unclear’ risk of bias. Model validity was compromised. Proof supporting individualised homeopathy remained inconclusive. Discussion The trials were positive (evidence level A), but inconsistent and suffered from methodological heterogeneity, incomplete study reporting, inadequacy of independent replications and small sample sizes. Further trials are warranted.
Phyllodes tumours (PTs) of the breast are rare biphasic fibroepithelial neoplasm. They have potentiality to recur and metastasise. Majority of them follow a benign clinical course. We have treated one patient suffering from PT at the out-patient department of Sri Ram Medical & Homoeopathic Research Centre, Gorakhpur, India. After detailed case taking and repertorisation, first Conium maculatum and later on Phytolacca decandra and Calcarea fluorica were prescribed on the basis of individualisation to treat the case. Outcomes were assessed clinically every month for subjective improvement and objectively by ultrasonography reports at every 6-month interval. Gradual improvement was noted over time. The case has been assessed with MONARCH Inventory, which shows ‘definite’ association between the medicine and the outcome.
Achtergrond Fibroadenoom van de borst is de meest voorkomende kwaal bij vrouwen met een aanzienlijk risico op overlijden. Uit de beschikbare literatuur blijkt dat borsttumoren verdwijnen door homeopathische behandeling. De huidige studie evalueerde de rol van homeopathische behandeling op borstfibroadenoma met behulp van ‘Triple assessment criteria’ (dubbel blind) en onderzoekt of homeopathische geneesmiddelen therapeutisch effect teweeg brengen door het veranderen van de oestrogeen en progesteron receptor (ER/PR) status op tumorweefsel. Materialen en Methoden Een open-label, prospectieve, single-arm, observationele studie werd uitgevoerd bij 64 vrouwelijke patiënten met fibroadenoom van de borst. Er werden drievoudige beoordelingscriteria gebruikt om de doeltreffendheid van de homeopathische behandeling van borstfibroadenomen te onderzoeken. Geïndividualiseerde homeopathische geneesmiddelen werden voorgeschreven. De meetresultaten vertoonden veranderingen in het klinisch beeld en het aantal en de omvang van de knobbels door middel van ultrasoonmammografie. ER/PR studie werd uitgevoerd door immunohistochemie met gebruik van quick score analyse. Resultaten Bij 23 gevallen (35,93%) van fibroadenomen was er na de behandeling geen knobbel meer meetbaar. Gedeeltelijke verbetering werd waargenomen in 22 gevallen (34,37%) met significante vermindering van de gemiddelde grootte (p < 0,001). Ook werd een significante vermindering van het aantal laesies gezien bij fibroadenomen (p < 0,05). Conium maculatum en Phytolacca decandra bleken de meest bruikbare remedies te zijn. De quick score waarde van ER na behandeling toonde significante vermindering (Z ¼ 4.910). Conclusie De studie toont aan dat de therapeutische effecten van toediening van geïndividualiseerde homeopathische geneesmiddelen een belangrijke rol spelen bij de behandeling van fibroadenomen van de borst. De resultaten van ER/PR laten een significante vermindering van ER zien, wat suggereert dat homeopathische geneesmiddelen een remmend effect hebben op ER.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.