A Systematic Review of Controlled Trials of Homeopathy in Adverse Effects of Radiotherapy and Chemotherapy in Cancer

Shukla, Purnima; Nayak, Chaturbhuja; Baig, Mirza; Misra, Purak

doi:10.1055/s-0039-1698827

Cited by 3 publications

(1 citation statement)

References 24 publications

(23 reference statements)

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“…Recent studies suggest that patients with cancer (average 31.4%) used complementary therapy at some stage of their illness, and homeopathic medicines might be used to enhance survival and improve quality of life in cancer patients. 27 Studies with breast cancer patients and estimating the ER/PR status with homoeopathic intervention can be replicated in controlled trials with methodological rigors. Even rigorous trials with robust methodology are warranted with homoeopathic interventions for benign lesions of the breast along with the pre-and post-ER/PR status.…”

Section: Implications For Future Researchmentioning

confidence: 99%

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Shukla

Misra

et al. 2020

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Background Fibroadenoma of breast is the commonest ailment of women with significant morbidity. Available literature revealed that breast tumour recedes by homoeopathic treatment.The present study evaluated the role of homoeopathic treatment on breast fibroadenoma by using ‘Triple assessment criteria’ and to explore the mechanism, whether homoeopathic medicines bring their therapeutic effect by altering the oestrogen and progesterone receptor (ER/PR) status on tumour tissue. Materials and Methods An open label, prospective, single arm, observational study was conducted on 64 female patients having fibroadenoma of breast. Triple assessment criteria were used to explore the effectiveness of homoeopathic treatment on breast fibroadenoma. Individualised homoeopathic medicines were prescribed. The outcome measures were changes in clinical picture, number and size of lump by ultrasonomammography. ER/PR study was performed by immunohistochemistry using quick score analysis. Results Post-treatment response of 23 cases (35.93%) of fibroadenoma revealed disappearance of lump. Partial improvement was noticed in 22 cases (34.37%) with significant reduction in mean size (p < 0.001). Similarly significant reduction in number of lesions was seen in fibroadenoma (p <0.05). Conium maculatum and Phytolacca decandra were found to be the most useful remedies. Quick score value of ER after treatment showed significant reduction (Z = 4.910). Conclusion The study revealed that the therapeutic effects of individualised homoeopathic medicines play significant role in management of fibroadenoma of breast. The results of ER/PR show significant reduction in ER suggesting that homoeopathic medicines have some inhibitory effect on ER.

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Section: Implications For Future Researchmentioning

confidence: 99%

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Shukla

Misra

et al. 2020

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Benefits of Homeopathic Complementary Treatment in Patients With Breast Cancer: A Retrospective Cohort Study Based on the French Nationwide Healthcare Database

Medioni

Scimeca²,

Marquez

et al. 2023

Clinical Breast Cancer

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Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Shukla¹,

Misra

et al. 2021

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Achtergrond Fibroadenoom van de borst is de meest voorkomende kwaal bij vrouwen met een aanzienlijk risico op overlijden. Uit de beschikbare literatuur blijkt dat borsttumoren verdwijnen door homeopathische behandeling. De huidige studie evalueerde de rol van homeopathische behandeling op borstfibroadenoma met behulp van ‘Triple assessment criteria’ (dubbel blind) en onderzoekt of homeopathische geneesmiddelen therapeutisch effect teweeg brengen door het veranderen van de oestrogeen en progesteron receptor (ER/PR) status op tumorweefsel. Materialen en Methoden Een open-label, prospectieve, single-arm, observationele studie werd uitgevoerd bij 64 vrouwelijke patiënten met fibroadenoom van de borst. Er werden drievoudige beoordelingscriteria gebruikt om de doeltreffendheid van de homeopathische behandeling van borstfibroadenomen te onderzoeken. Geïndividualiseerde homeopathische geneesmiddelen werden voorgeschreven. De meetresultaten vertoonden veranderingen in het klinisch beeld en het aantal en de omvang van de knobbels door middel van ultrasoonmammografie. ER/PR studie werd uitgevoerd door immunohistochemie met gebruik van quick score analyse. Resultaten Bij 23 gevallen (35,93%) van fibroadenomen was er na de behandeling geen knobbel meer meetbaar. Gedeeltelijke verbetering werd waargenomen in 22 gevallen (34,37%) met significante vermindering van de gemiddelde grootte (p < 0,001). Ook werd een significante vermindering van het aantal laesies gezien bij fibroadenomen (p < 0,05). Conium maculatum en Phytolacca decandra bleken de meest bruikbare remedies te zijn. De quick score waarde van ER na behandeling toonde significante vermindering (Z ¼ 4.910). Conclusie De studie toont aan dat de therapeutische effecten van toediening van geïndividualiseerde homeopathische geneesmiddelen een belangrijke rol spelen bij de behandeling van fibroadenomen van de borst. De resultaten van ER/PR laten een significante vermindering van ER zien, wat suggereert dat homeopathische geneesmiddelen een remmend effect hebben op ER.

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A Systematic Review of Controlled Trials of Homeopathy in Adverse Effects of Radiotherapy and Chemotherapy in Cancer

Cited by 3 publications

References 24 publications

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

Benefits of Homeopathic Complementary Treatment in Patients With Breast Cancer: A Retrospective Cohort Study Based on the French Nationwide Healthcare Database

Homoeopathic Management of Breast Fibroadenoma—An Open Label, Single Arm, Observational Trial

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