The present research work is to develop accurate and precise UV and HPLC method development for analysis Efavirenz in their capsule dosage forms and its validation. UV method for Efavirenz in their capsule dosage forms was developed by using the spectrum mode of analysis of SHIMADZU 1800UV /Visible spectrophotometer. Method was developed by using methanol as a solvent. By scanning, the each solution was in the range of 200-450 nm. 245 nm was selected as a wavelength for Efavirenz Capsule method was validated with the help of parameter as linearity, range, accuracy, precision (intraday and interday),LOD LOQ, Ruggedness, Robustness. HPLC method for analysis of Efavirenz in their capsule dosage forms was developed by using HPLC system of JASCO UV -2075 with ,Column Intersil ODS-3V (250 x 4.6mm) columns chromatogram for was developed using mobile phase methanol :Isopropanol in the ratio of 80:20 v/v. Retention time was achieved with 3.35 min ,flow rate 0.5ml/min ,wavelength 245nm respectively. Method was validated with the help of parameter as linearity, range, accuracy, precision (intraday and interday), LOD, LOQ, robustness.
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