Background: In Tamil Nadu, where health indicators are above the national average and routine immunization coverage is >95%, the tepid response to Measles-Rubella (MR) mass vaccination campaign was unexpected. Several parents refused MR vaccine for their children, due to false news claiming inefficiency and adverse effects due to the vaccine. Aim: This study was conducted to assess the Measles-Rubella (MR) mass vaccination coverage and to know the motivating factors and barriers for vaccination. Methods: A cross-sectional study was conducted in a rural area immediately following the mass vaccination campaign. Using a pre-tested structured questionnaire, data was collected on awareness of MR vaccination campaign, MR vaccination status, motivating factors and reasons for non-acceptance of the vaccine. Results: Vaccine coverage among the 616 children surveyed was 80.2%. Factors that motivated acceptance of vaccine among the immunized participants were easy access to immunization (85%), support and motivation from school teachers (41.1%) and community level health workers (25.5%). Barriers reported among the unimmunized participants were rumours of adverse effects (47.5%), fear of adverse effects (53.3%), and no faith in immunization (18.9%). Risk factors for vaccine refusal included female child (OR = 1.7, 95%CI = 1.1-2.6), Children not attending school (OR = 3.32, 95%CI = 2.1-5.1), Mothers with higher education (OR = 4.3, 95%CI = 1.2-15.2). Conclusion: An effective communication strategy addressing the needs and concerns of the public/parents should be in place and started early on before initiation of the mass vaccination programme.
Breast cancer is second most common in women and accounts for 23% of all occurring cancers in women. Patients with breast cancer have increasingly shown resistance and high toxicity to chemotherapeutic drugs. Plant-derived products have proved to be an important source of anti-cancer drugs. The present study was to investigate the anti cancer activity of ethanolic extract of Trachyspermum ammi against MCF-7 cell lines. The preliminary phytochemical studies of ethanolic extract of Trachyspermum ammi showed the presence of flavanoids, alkaloids, glycosides, steroids, carbohydrates, phenols, tannins and terpenes. The IC50 concentration of ethanolic extract of Trachyspermum ammi was determined by MTT assay. The results showed the greater degree of cytotoxicity at the dose of 25µg/ml of Trachyspermum ammi and it has been taken as IC50 value for our further study. Then, we also evaluated the apoptotic effect by measuring the morphological changes, cell viability rates using light and fluorescent microscopical studies and DNA fragmentation by using gel electrophoresis method. The ethanolic extract of Trachyspermum ammi showed significant signs of apoptosis such as cell shrinkage, membrane blebbing and nuclei DNA fragmentation. Further, we analyze the gene expression mRNA levels by using RT-PCR method, it showed the expression of p53 was significantly (P<0.001) increased when compared with normal MCF-7 cell line. The expression of anti apoptotic gene Bcl-2 was significantly (P<0.01) reduced when compared with MCF-7 cell line. From this study we conclude that ethanolic extract of Trachyspermum ammi having significant anticancer activity against MCF-7 cell lines and it might be good therapeutic value for further investigation to develop natural compounds as a anti tumor agents.
The study signifies the upcoming and recent technological trends used by companies to recruit the candidates through campus recruitment among colleges. The study also aims at the importance of placement cell among colleges for the further campus hiring process, it, therefore, analyses the recent techniques and strategies used by the companies. The study also paves the way in identifying the talented and qualified candidates through varied interviews, thus gathers about information on job feasibility provided for young students. Recent times have also paved the way for young minds to get into the world of e-recruitment. The Economic Times also stated in a 2019 report on how IIT graduates gave up on their dollar dreams for start-ups and new-age tech companies, which reflected in changing the corp landscape. The descriptive research design is used for the study. The universe of the present study is done in various colleges in Chennai among final-year students and campus placement co-ordinators. The sample size used for the study is 60. The Sampling method used for the study is the Non-Probability sampling method with a Convenient sampling type. Both the primary data and secondary sources of data are used in the study. The primary data used in the study is the questionnaire method. The secondary sources used in the study are E-Books, E-Journals, E-Articles, Google Scholar website, Shodhganga-Inflibnet, other literary searches. The statistical test reveals the significant difference between the gender of the respondents and the emotional impact of students getting filtered in campus placement gets depressed because most of the students may feel campus placement could play a vital role in their life.
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