Background
In view of the increasing prevalence of obesity in children, it is necessary to investigate the relative performance of different indicators used for its assessment and health consequences.
Objectives
To examine concordance between various indicators used for assessing obesity among adolescents and to examine their ability to predict risk of high systolic blood pressure.
Design
Cross-sectional study, from two schools catering to affluent class.
Subjects
Children in age 9–16 yr (n = 1146 boys and 1036 girls).
Measurements
Body weight, height, skinfold thickness at triceps (TSFT) and body fat percent by trained investigators and blood pressure measurement by a pediatrician using sphygmomanometer.
Results
Prevalence of overweight was lowest with criterion of TSFT (11.7% in boys; 7.6% in girls) and was highest using criterion of body fat percent (53.7% in boys and 28.4% in girls). Body mass index (BMI) had high significant correlation with each of the indicator and with systolic blood pressure (SBP) as well, in both sexes. All the indicators with conventional cut offs showed poor sensitivity for predicting high SBP. However, receiver operating characteristics (ROC) cut-offs improved sensitivity considerably, but the values were much lower compared to conventional cut-offs.
Conclusions
There is considerable disparity in the estimates of overweight children obtained by different indicators. Lower values of ROC cut-offs highlights the need for population specific customized classification systems for assessing obesity in view of the probable population differences in relative risks of non-communicable adult diseases.
We investigated the association between iron status, B12, and inflammatory markers among 101 adolescent girls. We found that B12 showed significant negative association with tumor necrosis factor-alpha (TNF-α) (rs = -0.232, P = 0.020) and positive association with serum ferritin (SF) (rs = 0.209, P = 0.036) among girls. Our results showed that hepcidin discriminates anemic and non-anemic population under normal B12 conditions. The logistic regression analysis revealed that the risk of having higher TNF-α levels was 13.2 times higher in low B12 girls in the presence of anemia compared to the girls having normal hemoglobin and B12 levels.
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