Background: Prehypertensive subjects have greater risk of developing hypertension than the normotensive subjects. Studies have shown that lipid profile is altered in hypertensive patients as compare to normotensive subjects. But not much is documented about lipid profile in prehypertensives. So the present study is done to compare the serum lipid profile among prehypertensive and normotensives and to correlate the blood pressure and lipid profile in prehypertensives. Methods: 50 prehypertensive and 50 normotensive subjects were recruited from the general population. Blood pressures were recorded and serum lipid profiles were measured and compare using student t test. Correlation of serum lipid profile and blood pressure was done using person correlation. Results: The study results showed significant increased in total cholesterol, LDL, VLDL and serum triglyceride level in prehypertensives compare to normotensives. While there is no significant change in HDL level in prehypertensive compare to normotensive. And there is also a significant correlation between blood pressure and lipid profile in prehypertensive subjects. Conclusion: Lipid profile is altered in prehypertensives compare to normotensives. That's why timely diagnoses and life style modification is required in prehypertensives.
Background: Natural history and disease progression in patients with Idiopathic Parkinson’s Disease (PD) is quite heterogeneous. Autonomic dysfunction occurs commonly among Idiopathic PD patients. Today, autonomic dysfunctions, including neurogenic orthostatic hypotension (OH), are well‐recognized nonmotor symptoms of patients with PD of all stages. Strong evidence suggests that autonomic dysfunction can actually present as one of the earliest prodromal symptoms occurring years before motor symptoms appear.Most patients with PD describe autonomic symptoms at the time of diagnosis suggesting that these features may have potential sensitivity as clinical biomarkers of the premotor phase. The recognition that damage to peripheral autonomic neurons is present in the early stages of Parkinson disease has led to a search for specific abnormalities in autonomic function that could serve as predictive biomarkers.Hence, Heart rate variability and blood pressure monitoring are used to assess cardiac autonomic dysfunction. The present study aimed to record heart rate variability and supine hypertension in PD patients and to correlate them with the age of onset, duration and severity of the disease, and non‐motor symptom burden. Material and Methods: The sample size is calculated to 50 PD patients in this cross‐sectional study. Disease severity was assessed by Webster rating scale. Non‐motor symptom burden was determined using the Non‐Motor Symptom Scale (NMSS). Ambulatory blood pressure monitoring and heart rate variability were determined. HRV was determined by LF and HF oscillations. Supine hypertension was defined as Systolic Blood Pressure (SBP) ≥150 mmHg and/or DBP ≥90 mmHg. Results: Age of onset was 60.9 ± 7.5 years and duration of disease was 1.5 ± 1.4 years. Mean Webster and non‐motor symptom scores were 12.7 ± 4.4 and 15.5 ± 8.0, respectively. About 41 patients (83%) were normal and no fluctuations, while 9 (17%) had supine hypertension.LF (r = −0.35), HF (r = −0.43), SDNN (−0.40), RMSSD (r = −0.41), NN50 (r = −0.38), PNN50 (r = −0.42), mean SBP (r = 0.26), and mean DBP (r = 0.33) correlated significantly with disease duration. PNN50 (r = −0.255), mean SBP (r = −0.29), and mean DBP (r = −0.27) correlated significantly with age at onset.Low Frequency oscillations (LF) (r = 0.27), High Frequency oscillations (HF) (r = 0.28), Standard Deviation NN intervals (SDNN) (0.26), and Root Mean Squared Successive Differences of NN intervals (RMSSD) (r = 0.27) correlated significantly with non‐motor symptoms scale. Conclusion: Heart rate variability (HRV) parameters are of significant help in the detection of early cardiovascular autonomic dysfunction and correlate significantly with disease duration, age of onset and non‐motor symptom burden among PD patients. Supine hypertension is common in PD patients hence need attention All India Institute of Medical Sciences, Bilaspur H.P 174001 This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
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