Mammary adenocarcinomas with metastases are more common in dogs than in cats. Their incidence is 1 in every 4,000 cats. In routine veterinary practice, laboratory exams for diagnosis of these neoplasms are nonspecific and scarcely used. Even though invasive procedure, biopsy, and histopathological findings are the gold standards that define the clinical approach, the clinical evaluation, and image assessment lead the way to the proper treatment, especially when surgical intervention is a possibility. This study describes the clinical signs, histopathological aspects, radiological and scintigraphic findings of a cat with mammary adenocarcinoma and metastases evaluated one hour after intravenous administration of 99mTc-thymine. Our focus was not to discuss the pathological aspects of the disease but the Nuclear Medicine role in metastases detection. Metastases, when lesser than 4mm, could go unnoticed by radiological exams, whereas scintigraphy may detect them. Using 99mTc-thymine scintigraphy, we successfully detected unsuspected metastases in the lungs, liver, and right kidney. Early diagnosis is the key to a better rate of survival due to the given treatment and prognostic. Hence, we strongly recommend the use of 99mTc-thymine scintigraphy as a complementary tool for breast cancer diagnosis in veterinary care.
O tumor venéreo transmissível canino (TVTC) é descrito na literatura como raramente metastático. Entretanto, métodos acurados para verificação dessa afirmativa não estão disponíveis na rotina veterinária. Neste trabalho utilizou-se a cintilografia com 99mTc-Timina para avaliar a disseminação do TVTC com apresentação cutânea. Houve captação da 99mTc-Timina nos três casos de TVTC estudados. A cintilografia com 99mTc-Timina é uma técnica não-invasiva e promissora para a avaliação do grau de disseminação tumoral em casos de TVTC. Sugerimos o seu uso na Oncologia Veterinária para localização de TVTC.
Mammary adenocarcinomas with metastasis are more common in dogs than in cats. Its incidence is 1 in every 4,000 cats. Usually, veterinary routine laboratory exams are nonspecific for these neoplasms and tumoral markers are not widely used in the practice. The clinical evaluation and image assessment leads the way to the proper treatment, especially when surgical intervention is a possibility. Although an invasive procedure, biopsy and histopathological findings are the gold standards which define the clinical approach. Procedures: This study describes the clinical signs, histopathological aspects, radiological and scintigraphic findings of a cat with mammary adenocarcinoma and metastasis evaluated one hour after intravenous administration of 99mTc-Thymine. Our focus is not to discuss the pathological aspects of the disease but the nuclear medicine role in metastasis detection. Metastasis when lesser than 4mm, could be unnoticed by radiological exams whereas scintigraphy may detect it. Results: Here, we successfully detected unsuspected metastasis in lungs, liver and right kidney. Early diagnosis is the key for a better rate of survival due to the given treatment and, prognostic. Conclusions: We strongly recommend the use of 99mTc-Thymine as a complementary tool for breast cancer diagnosis in veterinary care.
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