Combination therapy with two azoles was attempted with some success for clinical cure.

Primary cutaneous amoebiasis is extremely rare. Diagnosis is usually not suspected because of its rarity. Cutaneous amoebiasis responds readily to proper treatment, yet, if unrecognized and neglected, produces significant morbidity and may be fatal.

During the study period there were 2063 live births. Of these 573 (27.8%) were low birth weight (LBW), 277 (13.4%) preterm and 148 (7.1%) small for date (SFD) babies. In all, 263 (12.7%) newborns suffered from one or the other morbidity. Birth asphyxia of varying severity developed in 130 (6.3%) babies [88 LBW and 42 normal birth weight (NBW) (p < 0.001)]. Respiratory distress syndrome was diagnosed in 82 (3.9%) babies, most being due to hyaline membrane diseases (31.7%), which affected 26 (9.4%) of preterm babies. Deep infections were seen in 109 (5.3%) newborns [60 LBW and 49 NBW, (p < 0.001)] and superficial infections were seen in 79 (3.8%) babies [46 LBW and 33 NBW, (p < 0.001)]. Hyperbilirubinemia was detected in 78 (3.8%) babies. In one fifth of the babies, the cause of hyperbilirubinemia remained unidentified even after detailed investigations. Hypothermia was observed in 59 (2.9%) newborns [48 LBW and 11 NBW, (p < 0.001] and congenital malformations were seen in 24 (1.7%) babies. Morbidity was found to be high amongst LBW and preterm babies. The incidence of deep infections and hypothermia was high in our study.

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A total of 23,007 clinical samples, 2,001 were identified as Escherichia coli (E.coli). Among these, 205 strains were haemolytic. One hundred eighty one E.coli were found haemolytic among urinary isolates. Two tests i.e. salt aggregation test (SAT) and haemagglutination test (HAT) with human type A erythrocytes were performed to know the incidence of fimbriated strains amongst haemolytic E.coli isolates. Mannose resistant haemagglutination and Mannose sensitive haemagglutination was observed in 95 (46.34%) and 15 (7.31%) strains respectively. Whereas cell surface hydrophobicity was shown by 139 (67.80%) strains. Seventy nine (38.53%) strains were both SAT and HAT positive. Twenty nine (14.14%) strains were both SAT and HAT negative i.e. non-fimbriated strains. Among urinary isolates, 21.8% were found to possess both haemolytic and haemagglutinating activity. Haemolytic activity of E.coli was found associated with fimbriated strains. Thus, both act as virulence factors for the pathogenesis of Urinary Tract Infection.

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