To improve the pharmacokinetic and pharmacodynamics activity of the drug medication system like nanoparticles has made a break through by means of physical application. By means of targeted drug delivery system the targeted drug delivery will be achieved quickly.To maintain a controlled and sustain the rate of drug exposure on the site of action nanoparticles are used. That's the reason why the nanotechnology became as the most advanced in the field of medicine by maintaining the therapeutic benefits.Scientists performing many trails in the field of nanotechnology to reformulate the existing essential drugs to minimize the adverse effects and to increase the therapeutic effects. Some of the innovative concepts like nano-delivery, sustain release, etc have already became a breakthrough. The main concept of the paper is to elevate the basic concepts to use in the field of nanoparticles preparation and advantages.
The present study investigates the potential of antiurolithiatic activity of ethanolic extract of Taxillus tomentosus plant (EETT). Urolithiasis was induced by feeding the 0.75% of Ethylene glycol (EG) and 2% of Ammonium chloride (AC) in drinking water along with the normal feed in male wistar rats and then the anti-urolithiatic activity of EETT was evaluated. Acute toxicity study was conducted by LD50 cutoff dose of 2000mg/kg body weight (BW), indicates that the drug to be much safer and 1/10 th (200mg/kg BW) and 1/5 th (400mg/kg BW) of LD50 doses were selected for study. Serum and urine samples were analyzed for knowing the concentration of creatinine, calcium, urea, uric acid, oxalates and during the entire study, urolithiatic animals showed significantly high concentrations than normal animals. The EETT (200mg/kg BW and 400mg/kg BW) was showed good response to antiurolithiatic activity when compared to the standard drug cystone (CST).
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