The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.51-4.09; p = 0.0004) compared with GG+GA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p = 0.019; OR 0.71; 95% CI 0.54-0.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.
Degradation of environment is one of the most serious challenges before the mankind in today's world. Mankind has been facing a wide range of problem arising out of the degradation of environment. Not only the areas under human inhabitation, but the areas of the planet without human population have also been suffering from these problems. As the population increase day by day, the amenities are not improved simultaneously. With the advancement of science and technologies the needs of human beings has been changing rapidly. As a result different types of environmental problems have been rising. Environmental degradation is a wide-reaching problem and it is likely to influence the health of human population is great. It may be defined the deterioration of the environment through depletion of resources such as air, water, and soil. The destruction of ecosystem and extinction of wildlife. Environmental degradation has occurred due to the recent activities in the field of socio-economic, institute and technology. Poverty still remains a problem as the root of several environmental problems to create awareness among the people about the ill effect of environmental pollution. In the whole research it is clear that all factors of environmental degradation may be reduced through-Framing the new laws on environmental degradation, Environment friend policy, Controlling all the ways and means of noise, air, soil and water pollution, Through growing more and more trees and by adapting the proper sanitation policy.
Background: Nearly every family in the world is touched by cancer, which is now responsible for almost one in six deaths globally. Aim of this study was to access Indian woman's awareness towards cervical screening methods to promote strategies for increasing its uptake.Methods: A comprehensive questionnaire based cross-sectional observational survey was conducted in Pt. JNM Medical College and Dr. BRAM hospital, Raipur, Chhattisgarh from September 2018 to July 2019. Participants were selected by sampling between 21 to 59 years of age who have given consent for study.Results: Out of 1008 participants only 336 (33.3%) participants were aware about screening of cervical cancer and less than 28% participants were aware about pap smear, time of investigation, method of pap smear, health centre, association of HPV virus with cervical cancer, availability at vaccination, and with regard to risk factors only 27.9% women were aware that there is increased risk of cervical cancer due to multiple partners, 17.6% aware of risk due to increase in number of children’s, 11.1% aware of increase in risk of cervical cancer due to early initiation of sexual activity. Younger women (age 30-35, odds ratio 1.24, 95% CI 0.78-1.32, p-value 0.05), low socioeconomic status (odds ratio 1.74, 95% CI 0.76-2.12, p-value 0.01), education level (≤ secondary education odds ratio 1.64 95% CI 0.85-2.18 p-value 0.000, ≥ higher secondary or above education odds ratio 2.32 95% CI 1.21-2.89 p-value 0.001) and age at marriage (odds ratio 2.21, 95% CI 0.78-2.18, p-value 0.000) all had a significant relationship with the awareness of Pap smear test. Two-third of the females in the study stated that lack of awareness as the major reason for not getting a pap smear while another one- third stated lack of recommendation by health care professionals as major hurdle.Conclusions: This study found that woman's fear, pain and embarrassment, along with cultural influences, deterred them from undergoing screening.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.