For thousands of years mankind is using plant sources to alleviate or cure illness 1. Novel chemical compounds synthesis from the plant active constituents, which are of potential use in medicine and other usefull application. Herbal remedies are popular remedies for diseases used by a vast vast majority of the world's population 2. Herbal plants having many pharmacologically active compounds like flavonoids, alkaloids, tannin, steroids, glycosides, phenols, fixed oils, which is stored in their specific parts of leaves, bark, flowers, seed, fruits, root etc. 3. Biophytum sensitivum (family-Oxalidaceae) having different pharmacological activities such as dengu,anticancer, antiinflammatory, chemoprotective, antidiabetic and wound healing activities of their different parts 4-8 .

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have posed a problematic healthcare situation worldwide since December 2019. Diabetes mellitus is associated with an increased risk and severity of coronavirus disease 2019 (COVID-19). While interacting with various other risk factors, high blood sugar was found to reduce immunity and increase the replication of SARS-CoV-2. Oxidative stress and the release of pro-inflammatory cytokines are greater in diabetic individuals than in healthy people, worsening the outcome of SARS-CoV-2 infection in diabetics. Increased expression of furin and angiotensin converting enzyme 2 (ACE-2) receptor in the hyperglycemic environment may promote the entry of SARS-CoV-2 in the host cell. COVID-19 infection primarily modulates immune and inflammatory responses, and may cause a cytokine storm, resulting in possible lethal outcomes in diabetics. An experimental report suggests that ACE expressed in the pancreas and the SARS-CoV-2 virus invariably destroy β-cells which contain ACE-2 receptors and results in acute diabetes. Moreover, COVID-19 also causes hyperglycemia in an individual with diabetes which may be related to insulin resistance and destruction of β-cells during SARS-CoV-2 infection. Early observations also suggest a correlation between oral hypoglycemic agents and the risk of COVID-19. This review focused on the possible cause and mechanism involved in SARS-CoV-2 infection in diabetics and the role of antidiabetic drugs in COVID-19.

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