An efficient, regioselective and diastereoselective synthesis of diversely functionalized spirooxindoles under microwave irradiation in aqueous medium; most of the compounds show significant antimicrobial activities.
A one‐pot protocol has been demonstrated for the regioselective sulfenylation of imidazoheterocycles with disulfides. In this method, thiols are converted to sulfenyl bromides and reacted with 2‐phenylimidazo [1, 2‐a] pyridines. This simple procedure is highly capable for sulfenylation with readily available starting materials in good to excellent yields under transition metal and base free conditions.
A transition‐metal‐free and a mild multicomponent methanolysis protocol has been developed to access pyrrole and pyrolizine derivatives from readily available substrates ninhydrin, alkyne and amine. The reaction works well with both primary and secondary amines with a simple variation in temperature. The reaction is proposed to go through a (3+2) cycloaddition reaction via azomethine ylide intermediate.
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