The multicomponent reaction between isatin, amino acid, but-2-ynedioates, and phenacyl bromide has been developed using microwave irradiation under catalyst and base-free conditions in aqueous medium. This synthetic protocol is useful for the synthesis of various functionalized spirooxindole derivatives. This MCR exhibits a broad substrate scope with excellent yields and shorter reaction time. Additionally the synthesized spirooxindole derivatives were evaluated for their anticancer activity against three human cancer cell lines: MCF-7 (breast), A549 (lung), and HeLa cervical. Most of the compounds showed moderate to potent cytotoxic activity against the tested cell lines.
An efficient one-pot multi-component protocol has been developed for the synthesis of novel spiro-fused pyrrole/pyrrolizine/thiazole derivatives using (3+2) cycloaddition reactions; all products were obtained in moderate to excellent yields and synthesized from commercially available starting materials.
A transition‐metal‐free and a mild multicomponent methanolysis protocol has been developed to access pyrrole and pyrolizine derivatives from readily available substrates ninhydrin, alkyne and amine. The reaction works well with both primary and secondary amines with a simple variation in temperature. The reaction is proposed to go through a (3+2) cycloaddition reaction via azomethine ylide intermediate.
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