Oral squamous cell carcinomas (OSCC) are common malignancies that affect almost a million people every year. The key issue in reducing mortality and morbidity associated with OSCC is to develop novel strategies to identify OSCC at an early stage. One such strategy is the identification of biomarkers. So far, more than 100 biomarkers are recognized in the detection of oral cancer and they range from proteins to nucleic acids (DNAs, RNAs). Detection of ribose nucleic acids in saliva is a recent trend in diagnosing oral cancer. Studies have shown statistically significant changes in the levels of salivary transcriptomes in patients with oral squamous cell carcinomas. These biomarkers have displayed high sensitivity and specificity. Also, new point-of-care platforms such as oral fluid nanosensor test are now available that will soon emerge as chair-side tools for early detection of oral cancer. The aim of this review is to highlight the importance of salivary transcriptomes in oral cancer detection.

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Adenoid Cystic Carcinoma (ACC) is a rare tumor constitutes for less than 1% of head and neck malignancies and 10% of all salivary gland tumors. Palate is the most common site to be involved in the oral cavity followed by parotid gland and submandibular gland. They are usually asymptomatic, slow growing, characteristically shows infiltrative growth and perineural invasion. This paper reports a case of Adenoid Cystic Carcinoma in a 35 year old female man reported with a swelling on the left side of palate involving the hard and soft palate since 8 months which was diagnosed histopathologically and review of literature of the peculiar clinical, and histopathological features.

Highlights Sodium chloride causes inhibition in the replication of a range of DNA and RNA viruses. Saline water gargling and nasal irrigation represent simple, economical, practically feasible, and globally implementable strategies with therapeutic and prophylactic value. Saline water gargling and nasal irrigation are examples of harmless interventions. Saline water gargling and nasal irrigation are suitable options for the current crisis.

Despite the researchers' efforts, worldwide, more patients are diagnosed having cancer, and especially oral cancer. The book entitled "Oral Cancer Detection-Novel Strategies and Clinical Impact", coordinated by Dr. Prashanth Panta addresses all topics related to oral cancer, from precancerous lesions, epidemiology, imaging to histopathology. The book is divided into 15 chapters. The first chapters present general data on oral cancer, such as genetics and molecular mechanisms in oral cancer progression, respectively data on oral cancer epidemiology. After presenting standardized data for delayed diagnosis in oral cancer, the imaging methods used in oral cancer evaluation with the biopsy exam and histopathology in oral squamous cell carcinoma are also described. Assessment criteria for the clinical examination of the oral cavity are presented as the application of vital stains as adjuncts of clinical examination. Oral cancer investigations are consistently and convincingly described and illustrated by optical techniques, optical imaging, optical coherence tomography, bioimpedance, sensitive crystallization patterns, and salivary biomarkers. The book is clearly written, each chapter is abundantly illustrated, and is accompanied by up-to-date references on the subject. Dr. Prashanth Panta, along with a team of clinicians, has been able to provide the reader with an excellent monograph on oral cancer detection. Oral cancer screening should be part of every initial and periodical examination of the oral cavity. Therefore, every clinician should consult this book.

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The spectacle of Koebner’s phenomenon (KP) is interesting in that trauma precipitates a subset of pathologically distinct conditions, indicating the subtle interplay between sensitization and dermato-mucosal integrity. KP is interesting because, if factors initiating it are controlled, then it may be possible to prevent these debilitating conditions through induction of reverse Koebnerization. Herein, we present a report of a patient with an erosive lesion, localized to the occlusal plane on buccal and lingual mucosa, that interestingly subsided following 1 week after a dental scaling procedure. This report analytically describes the role of dental calculus and cuspal trauma as important triggers surrounding the genesis of oral lichenoid lesion and oral lichen planus. An engaging discussion on these closely related enigmatic entities forms the central theme of this report.