Oral route of administration gets the highest priority for the delivery of drug as well as better patient compliance. Floating tablet is selected for achieving a prolonged and predictable drug delivery profile in the gastrointestinal tract to control the gastric residence time using a gastro retentive dosage forms that will provide as with new and important therapeutic options. The design of oral controlled drug delivery systems is aimed primarily to achieve more predictable and increased bioavailability. However, this system have several physiological difficulties, such as inability to restrain and localized oral control drug delivery systems within desired reasons of the gastro intestinal tract and the highly variable nature of the gastric emptying process. Gastric emptying time in humans, which is normally 2-3 hours through the main absorption area (stomach or upper part of intestine), can result in incomplete drug release from oral controlled drug delivery system leading to diminished efficacy of an administered dose. Intimate contact of oral controlled drug delivery system with the absorbing membrane has the potential to maximize drug absorption and also influence the rate of drug absorption .These consideration have lead to the development of oral controlled gastroretentive dosage forms possessing gastric retention capabilities . Pantoprazole floating tablets is used to treat and prevent bacterial infections in the stomach and intestines. Keywords: Bioadhesive Floating Matrix, Pantoprazole, Polymers, sodium bi carbonate and citric acid, in vitro drug release studies.
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