Formulation and Evaluation of Pantoprazole Floating Tablets

Abstract

Oral route of administration gets the highest priority for the delivery of drug as well as better patient compliance. Floating tablet is selected for achieving a prolonged and predictable drug delivery profile in the gastrointestinal tract to control the gastric residence time using a gastro retentive dosage forms that will provide as with new and important therapeutic options. The design of oral controlled drug delivery systems is aimed primarily to achieve more predictable and increased bioavailability. However, this system have several physiological difficulties, such as inability to restrain and localized oral control drug delivery systems within desired reasons of the gastro intestinal tract and the highly variable nature of the gastric emptying process. Gastric emptying time in humans, which is normally 2-3 hours through the main absorption area (stomach or upper part of intestine), can result in incomplete drug release from oral controlled drug delivery system leading to diminished efficacy of an administered dose. Intimate contact of oral controlled drug delivery system with the absorbing membrane has the potential to maximize drug absorption and also influence the rate of drug absorption .These consideration have lead to the development of oral controlled gastroretentive dosage forms possessing gastric retention capabilities . Pantoprazole floating tablets is used to treat and prevent bacterial infections in the stomach and intestines. Keywords: Bioadhesive Floating Matrix, Pantoprazole, Polymers, sodium bi carbonate and citric acid, in vitro drug release studies.

Formulation and Evaluation of Orodispersible Tablets of a Model Anti-Hypertensive Drug

“…The cumulative drug release data obtained from formulations were subjected to different kinetic models such as zero-order kinetics, first-order kinetics, higuchi model, and Korsmeyer-peppas release model [21][22][23].…”

Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives

“…However, tablets containing the highest amount of HPMC (50% of a tablet mass), had the highest swelling index value [ 296 ]. A study by Reddy et al [ 297 ] compared the effects of HPMC and sodium alginate content in tablet mass on pantoprazole release. Floating tablets containing a mixture of both substances in different ratios and one of the polymers were prepared.…”

“…No significant differences were observed between the release profiles of the manufactured tablet batches. The optimized formulation containing only HPMC was characterized by a floating lag time of 60 s, a prolonged release of the drug substance of up to 8 h, and excellent stability during storage in climate chambers for one month [ 297 ].…”

Preparation, Characterization and Evaluation of Flavonolignan Silymarin Effervescent Floating Matrix Tablets for Enhanced Oral Bioavailability

“…Systems for floating medicine delivery have significant benefits, as they are less prone to gastric emptying, resulting in reduced subject variability in plasma drug levels [ 5 ], and are responsible for the delivery of drugs with low absorption values, increased dosing and reduced patient compliance [ 7 ]. GRDDS possess good results for acyclovir, ofloxacin and pantoprazole [ 8 , 9 , 10 , 11 ].…”