In present investigation attempt was made to design novel mold with aim to overcome the problems occurs during the casting of mouth dissolving films. Placebo and Perindopril Erbumine containing mouth dissolving film (MDF) were prepared with Pullulan, HPMC E-15 as film forming agent and other excipient by solvent casting method on specially design mold and regular petri dish. The HPMC E-15 125mg and Propylene Glycol 30 μ ml as plasticizer contains MDFs formulation (H2) were found to be optimized when compared with Pullulan on the basis of physical evaluation parameters like weight variation, drug, thickness in the range 0.01 -0.03 mm, disintegration time in <17sec. And release of drug from the film was found to <60sec and other parameters were found within acceptable limits. The prepared optimized stable mouth dissolving films were characterized by SEM, FT-IR, DSC etc. And various new equipments were used first time in PMDFs preparation for cutting, pill-out and water level indicator for balancing novel mold in the oven, which was widely used in other field like engineering and physics. Especially design mold for casting of the film was found to be more efficient than regular petri dish due to easily scale up and avoid problems occurs during preparation of stable mouth dissolving film which leads to reduce the wastage of active ingredients and excipients.
A new and facile one‐pot method for synthesis of the title scaffolds is presented and further extended by employing two other reactive ketones instead of isatin.
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