COVID-19 is considered as a major public health problem caused by the SARS CoV-2. This Viral infection is known to induce worldwide pandemic in short period of time. Emerging evidence suggested that the transmission control and drug therapy may influence the preventive measures extensively as the host surrounding environment and pathogenic mechanism may contribute to the pandemic condition earlier in COVID-19 disease. Although, several animals identified as reservoir to date, however human-to-human transmission is well documented. Human beings are sustaining the virus in the communities and act as an amplifier of the virus. Human activities i.e., living with the patient, touching patient waste etc. in the surrounding of active patients or asymptomatic persons cause significant risk factors for transmission. On the other hand, drug target and mechanism to destroy the virus or virus inhibition is depends on diversified approaches of drugs and different target for virus life cycle. This article describes the sustainable chemical preventive models understanding, requirements, technology adaptation and the implementation strategies in these pandemic-like situations. As the outbreak progresses, healthcare models focused on transmission control through disinfections and sanitization based on risk calculations. Identification of the most suitable target of drugs and regional control model of transmission are of high priority. In the early stages of an outbreak, availability of epidemiological information is important to encourage preventive measures efforts by public health authorities and provide robust evidence to guide interventions. Here, we have discussed the level of adaptations in technology that research professionals display toward their public health preventive models. We should compile a representative data set of adaptations that humans can consider for transmission control and adopt for viruses and their hosts. Overall, there are many aspects of the chemical science and technology in virus preventive measures. Herein, the most recent advances in this context are discussed, and the possible reasons behind the sustainable preventive model are presented. This kind of sustainable preventive model having adaptation and implementation with green chemistry system will reduce the shedding of the virus into the community by eco-friendly methods, and thus the risk of transmission and infection progression can be mitigated.
A trinuclear copper complex [Cu 3 (napxshz) 2 (phen) 2 ] has been synthesised using a tribasic naproxen-appended ligand [propanoyl) benzohydrazide] and 1,10-phenanthroline. The complex was characterised by different spectroscopic methods such as Fouriertransform infrared (FT-IR), ultraviolet-visible (UV-Vis) and electrospray ionisation (ESI)-mass spectroscopy. The solid-state structure of the ligand and complex 1 was established by single-crystal X-ray diffraction analysis. The interaction of the complex and the ligand with DNA was investigated by UV-visible spectroscopy and fluorometric titrations. The calculated binding constants (K b ) of the complex and the ligand with ct-DNA show that the complex has a higher binding affinity than the ligand H 3 napxshz. Quantum chemical calculations were performed to understand the structural aspects of the complex and its interactions with DNA. The molecular docking study reveals the interaction between DNA, and the complex is in intercalative mode.
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Nobody had ever imagined that the virus found on the Wuhan fish market would spread worldwide within a few months. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh member of the coronavirus family that infects humans. Going through the corona-lane, mankind has faced different virus variants, i.e., COVID-19, delta B.1.617.2, and Omicron B.1.1.529. The outbreak of COVID-19 created a shocking situation for not only the healthcare system, but also the post-COVID-19 world, which is witnessing huge damage in the field of environmental health, education, economy, industrial imbalance, hunger, indebtedness, crisis, etc. in most cases. Now, the wide level of vaccination throughout the world controls the number of cases, but by looking at the global scenario and the latest Chinese lockdown, it can be concluded that it will take time to become normal. The present article is an effort to present the COVID-19 journey, how the situation was, how it is, and how it may be. The perspective towards climate action and its impact on the United Nation’s Sustainable Development Goals of the United Nations have also been discussed.
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