An eight-year-old child presented with nasal discharge, stuffiness, and whitish polypoid swelling in the left nostril with Bitot's spot. Computed tomography (CT) evaluation showed complete involvement of the left nostril and maxillary sinus. Blood investigations revealed leukocytosis, raised absolute eosinophils, increased alkaline phosphatase, and reduced vitamin A levels. Histopathological examination revealed inflammatory infiltrate with Leishman-Donovan bodies, which confirms the diagnosis of mucosal leishmaniasis (ML). In the present case, the recording of demographic data is important as the child was a migrant from the leishmaniasis-endemic area of Bihar state, India. Nasal polypoid growth was removed by endoscopic surgery, followed by a combination of allopathic and polyherbal preparation. The child responded well to these therapeutic measures, and there was no recurrence of nasal discharge, stuffiness, and crustation at six-month follow-up.
Introduction: Oral Squamous Cell Carcinoma (OSCC) is the 3rd most common malignancy. In Indian scenario, oral submucous fibrosis is the most common condition associated with OSCC. Pre and postsurgical evaluation of serum Interleukin-6 (IL-6), Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) will help in predicting the prognosis, along with planning of postsurgical treatment protocol. The NLR and PLR are easily available and cost effective biomarkers from peripheral smear. Need of Study: The IL-6 and NLR are convenient and inexpensive prognostic markers, they could be widely available in routine clinical practice, which might serve as a valuable marker for predicting the prognosis of OSCC and assessing the magnitude of systemic inflammation. Aim: To compare the serum IL-6 with NLR and PLR in pre and postsurgical OSCC patients. Materials and Methods: A prospective analytical study, for duration of two years from December 2020 to October 2022 will be conducted at Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, Sawangi (Meghe), Wardha, Maharashtra, India, in which total 40 patients from lower and middle socio-economic status and histological confirmed cases of OSCC will be included, after obtaining an informed written consent. A detailed clinical, radiological and histological evaluation of all cases will be recorded in the structured format. Presurgical and postsurgical 5 mL venous blood will be collected for evaluation of IL-6, NLR, Platelet–Lymphocyte ratio. Data analysis will be done using unpaired‘t’ test. For categorical data, Chi-square test will be used to compare the proportions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.