Comparative Evaluation of Serum Interleukin-6 Expression with Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio in Pre and Post Surgery Oral Squamous Cell Carcinoma Patients: A Research Protocol

Bhargava, Pragati A; Bhowate, Rahul

doi:10.7860/jcdr/2022/58470.17343

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“…The present prospective analytical study was conducted in Department of Oral Medicine & Radiology, after approval from the Institutional Ethics Committee (DMIMS (DU)/IEC/2020-21/9427, dated 24/12/2020) and protocol of the study was published in December 2022 with no deviation in the study objective. 12…”

Section: Methodsmentioning

confidence: 99%

Comparative evaluation of serum interleukin 6 with neutrophil - lymphocyte and platelet -lymphocyte ratio in pre and post-surgery oral squamous cell carcinoma.

Bhargava

Bhowate

2023

F1000Res

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Background: Oral Squamous Cell Carcinoma is a major health burden in Asian countries necessitating the need for active research in terms of diagnosis and management. Various pro-inflammatory markers such as Interleukins, TNF Alpha, Interferon gamma and inflammatory mediators such as Neutrophils, lymphocytes, monocytes and mast cells are known to be involved in the tumor associated inflammatory status. Aim: To explore the role of Interleukin - 6, Neutrophil to Lymphocyte ratio and Platelet to lymphocyte ratio in Oral Squamous Cell Carcinoma in both pre and post operative conditions. Materials and Methods: Forty subjects who were Clinically and Histo-pathologically diagnosed, graded and staged based on TNM staging of OSCC included in the study. Pre and Post operative assessment of serum Interleukin-6, Neutrophil to Lymphocyte Ratio and Platelet Lymphocyte Ratio was carried out. Results: On evaluation significant difference was evident on comparison between the preoperative IL-6 levels and post operative levels. On evaluation of NLR, there was also a significant difference in preoperative NLR based on the staging of the tumor, the mean preoperative NLR higher in stage Iva than in stage III. On evaluation of PLR, the mean preoperative PLR differed significantly between stage III and stage IV a OSCC. However, no evaluative difference was noted in pre and post operative PLR based on the histopathological type of OSCC. But, there was a significant difference noted in the PLR levels between the pre and the post operative status. Conclusion: NLR and PLR are useful markers representing the stage of the tumor as higher values of NLR and PLR are associated with high stages of tumor. Pre and Post operative IL-6 and PLR can also be useful in post operative and post treatment inflammatory status in individuals affected with Oral Squamous Cell Carcinoma.

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Section: Methodsmentioning

confidence: 99%