SummaryA method for determining antiheparin activity of platelets and erythrocytes is described. The neutralization of various concentrations of heparin by various amounts of protamine sulphate or tested material is measured simultaneously. Results are expressed in mean equivalent of protamine sulphate (PS) standard solution. The normal values of antiheparin activity of platelets and erythrocytes in human and in various animals are given.
SummaryThe fibrinolytic system has been studied in 37 patients with essential hypertension, with arterial hypertension of various etiology (renal hypertension and hypertension with atherosclerosis). It has been found that in all these patients euglobulin fibrinolysis is inhibited and fibrinogen, factor VIII, plasminogen, plasminogen proactivator and antiplasmin increase considerably.On the basis of the above findings and other literature data, the authors present a hypothesis that the fibrinolytic system is involved in the regulation of arterial blood pressure and that the impairment of plasminogen activator production in the renal tissue is one of the contributory factors in the development of arterial hypertension.
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