Inhibition of dog fibrinolytic system in experimental tubular necrosis of kidney

Thrombosis Complicating Renal Amyloidosis in Dogs

“…Parenchymal changes in the diseased kidney thus may contribute to the decreased fibrinolytic activity and hypercoagulability noted in renal disease [12,13,22,301. Inhibition of the fibrinolytic system [25] and a state of hypercoagulability [33] have also been described in dogs with experimental renal tubular necrosis. Rats with aminonucleoside-induced nephrotic syndrome exhibit greatly decreased fibrinolytic activity and elevated plasma fibrinogen levels at the peak of the disease [21].…”

Effect of urokinase antiserum on plasminogen activators: demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase

“…Recent evidence, indicating (a) that activator concentration is higher in renal venous than arterial blood in both man and animals (34) and (b) that plasma activator concentration fell during mercuric chloride intoxication (9,25) and clamping of the renal vessels (10) suggests that the kidney may serve as a significant source of plasma activator. A clearing function for plasma activator by the liver is suggested by studies which detected increased levels of this activator in animals in which the hepatic vessels had been clamped (10), in humans with cirrhosis (35), and in animals in which liver transplantation was being performed (36).…”

Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis

“…It has been observed by others that the antifibrinolytic effect of serum resides largely with the a2-globulin fraction (7). It has further been shown that the kidney plays a role in the regulation of fibrinolysis (8)(9)(10) and that this system can become impaired with renal damage (11). Antifibrinolysin studies are unfortunately unavailable in our cases.…”

“…Under high magnification this material appeared very finely granular and did not resemble fibrin. It occasionally contained what appeared to be remnants of sub- [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. This was observed apparently unassociated with platelet aggregation in nine cases.…”