Simple, sensitive and accurate UV spectrophotometric method for simultaneous determination of Rosuvastatin and Telmisartan has been developed. The new method was developed with Methanol and phosphate buffer (pH 7.2) in proportion of 30:70 as solvent system. The several HPLC and UV spectroscopic methods were reported in literature for estimation of Rosuvastatin and Telmisartan. Therefore need to develop simple, more sensitive and economic method for simultaneous for estimation of Rosuvastatin and Telmisartan in bulk and in combined dosage form is described. Rosuvastatin showed at 276.30 nm and Telmisartan showed at 295.70nm. Linearity range was observed in the concentration range of 5-25µg/ml for Rosuvastatin calcium and 10-50µg/ml for Telmisartan. Percentage purity and recovery study were in the limit of 98-102% for both drugs. Limit of Detection for Rosuvastatin and Telmisartan were found to be 0.508µg/ml and 1.54µg/ml respectively. Limit of Quantitation for Rosuvastatin and Telmisartan were found to be 1.402 µg/ml and 4.25µg/ml respectively. The proposed method can be successfully used for the analysis of pure drug and marketed formulation. The method is found to be precise, simple, and accurate and can be applied for the routine estimation of Rosuvastatin and Telmisartan.
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