Extensive attempts have been made to decipher the problem associated with the
solubility of drugs for maximizing bioavailability at targeted sites. More than 40% NCEs (new
chemical entities) emerged through modern technology like high throughput screening, combinatorial
chemistry, computer-aided drug design etc. and the drug discovery process has been
dramatically accelerated. Fabrication of materials into the nanodimension changes their physical
properties which depicts a vivid shift from lab scale optimization studies to scale up focused
studies. In addition, this comprehensive review covers physics behind the drug nanocrystals and
their properties, different technologies and methods of drug nanocrystal preparation and its stabilization
along with theapplication of nanocrystals. This review also covers factors affecting
nanoformulations, post-production processing and future prospects.
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