Effect of cosurfactant addition on phase behavior and microstructure of a water dilutable microemulsion

Golwala, Pooja; Rathod, Sachin; Patil, Rahul; Joshi, Amita; Ray, Debes; Aswal, Vinod K.; Bahadur, Pratap; Tiwari, Sanjay

doi:10.1016/j.colsurfb.2019.110736

Cited by 32 publications

(29 citation statements)

References 38 publications

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“…Structural changes in corona were verified by extracting the structure factor S ( Q ) and the form factor P ( Q ) from the fitted SANS data of micelles [ 23 , 34 ]. In line with the above arguments, PLX-loaded micelles showed substantial deviation in S ( Q ), along the higher-length scale (low Q ) region.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis, Colloidal Characterization and Targetability of Phenylboronic Acid Functionalized α-Tocopheryl Polyethylene Glycol Succinate in Cancer Cells

et al. 2020

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This study reports targetable micelles developed after covalent functionalization of α-tocopheryl polyethylene glycol succinate (TPGS) with amino phenylboronic acid (APBA). Nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic results showed successful attachment of APBA to the hydrophilic segment of TPGS. Dynamic light scattering and small-angle neutron scattering studies revealed that the conjugate self-assembled in water to produce spherical core-shell micelles (14–20 nm) which remained stable against temperature (ca. 25–45 °C) and pH changes. The micelles could solubilize a high payload of paclitaxel (PLX) without exhibiting changes in the average size. However, at the saturation solubility, drug molecules migrated from the core to the shell region and engaged with APBA groups via π–π stacking interaction. Confocal microscopy and cell sorting analyses verified the effective translocation ability of TPGS-APBA micelles in sialic acid (SA) expressing MDA-MB-453 cells. At equivalent PLX dose, TPGS-APBA micelles showed about a twofold improvement in apoptotic death among the cells exposed for 2 h. Our findings indicate that the attachment of APBA can be a potential strategy for improving the intra-cellular localization of carriers among cancer cells expressing SA residues.

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Section: Resultsmentioning

confidence: 99%

“…The angular distribution of neutrons scattered by the sample was recorded using a one meter long, one-dimensional He 3 position-sensitive detector. For the analyses of structural parameters ( supplementary materials ), the data were fitted to the spherical particle model [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Colloidal Characterization and Targetability of Phenylboronic Acid Functionalized α-Tocopheryl Polyethylene Glycol Succinate in Cancer Cells

et al. 2020

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“…The physical condition of the ME was illustrated by one axis representing the aqueous phase, the other representing the oil, and the third indicating the fixed S mix ratio on pseudo-ternary diagrams. The ME region was described in the diagram as the area where visual inspection provided clean and transparent formulations (Brand et al., 2002 ; Golwala et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

et al. 2021

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Crotamiton (CRT) is a commonly approved drug prescribed for the scabies treatment in many countries across the globe. However, poor aqueous solubility and low bioavailability, and side effects restrict its use. To avoid such issues, an appropriate carrier system is necessary which can address the aforementioned challenges for attaining enhanced biopharmaceutical attributes. The current study intends to provide a detailed account on the development and evaluation of CRT-loaded microemulsion (ME) hydrogel formulation containing tea tree oil (TTO) for improved drug delivery for scabies treatment in a safe and effective manner. Pseudo-ternary phase diagrams were constructed with TTO as the oily phase, and Cremophor ® EL was used as the surfactant in a mass ratio 2:1 with co-surfactants (mixture of phospholipid 90G and Transcutol ® P), and aqueous solution as the external phase. The optimized drug-loaded ME formulation was evaluated for skin penetration, retention, compliance, and dermatokinetics. The nonirritant behavior of the formulation was revealed by skin histopathology, which showed no changes in normal skin histology. In comparison to the conventional product, dermatokinetic experiments revealed that CRT has greater penetration and distribution in the epidermis of the mice skin. The findings imply that the proposed lipid-based ME hydrogel can aid in the resolution of CRT issues by providing a better and safer delivery option to epidermis and deeper epidermis in substantial quantities.

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“…The second component of surface-active modulator mixture is the cosurfactant (CoS), also found as co-solvent, which has the property to decrease the interfacial tension, promoting a proper flexibility for the particles [232]. Cosurfactants (CoSs) are studied as penetration enhancers, being greatly appreciated in skin delivery.…”

Section: Formulation Of Microemulsionsmentioning

confidence: 99%

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

et al. 2020

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With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.

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Effect of cosurfactant addition on phase behavior and microstructure of a water dilutable microemulsion

Cited by 32 publications

References 38 publications

Synthesis, Colloidal Characterization and Targetability of Phenylboronic Acid Functionalized α-Tocopheryl Polyethylene Glycol Succinate in Cancer Cells

Synthesis, Colloidal Characterization and Targetability of Phenylboronic Acid Functionalized α-Tocopheryl Polyethylene Glycol Succinate in Cancer Cells

Crotamiton-loaded tea tree oil containing phospholipid-based microemulsion hydrogel for scabies treatment: in vitro , in vivo evaluation, and dermatokinetic studies

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

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