The relation between the type of hyperlipoproteinemia and the xanthoma type found in the same patient is discussed on the basis of literature and own observations. The cholesterol level of the blood gives not enough information on disturbances in the lipoprotein metabolism, at least also triglyceride and/or total lipid estimations should be performed. Xanthomata tendinea are characteristic for an enhanced low density lipoprotein level in the blood and are often accompanied by ischemic heart disease. Eruptive xanthomata and enhanced very low density lipoprotein (VLDL) levels belong together. The enhanced VLDL level may be favorably influenced by a reduction diet with a low proportion of carbohydrates.
An immediate depression of the rate of cell proliferation occurred upon addition of glucocorticosteroids to cultures of human skin fibroblasts in the early growth stages. A reduced sensitivity or even insensitivity of the fibroblasts to growth inhibition inhibition was found upon the addition of the steroids at later stages of cell growth, when the cell density has increased. The inhibition in the early growth stages is transient and is most pronounced if the cultured medium is not renewed. This transient inhibition is not due to the development of steroid-resistant cell lines, and resembles the effect called tachyphylaxis, as is also observed in vasoconstriction tests.
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