Abstract. DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR), a recently identified mTOR-interacting protein, is a novel candidate oncogene. Previous studies reveal that high DEPTOR expression is required to maintain PI3K and Akt activation and to inhibit apoptosis. However, its significance in differentiated thyroid carcinoma (DTC) is not yet known. The present study verifies the mRNA and protein expression of DEPTOR in five cell lines, DTC tissues and normal adjacent tissues. Tissue microarrays of 114 DTC patients were used to detect DEPTOR protein expression. The assessment of DEPTOR levels demonstrated that DEPTOR in DTC cells and tissues was significantly increased compared with normal cells and adjacent normal tissues. DEPTOR protein expression was significantly associated with lymph node status, extrathyroid extension and distant metastasis. Patients exhibiting high DEPTOR expression were statistically susceptible to earlier recurrence and poorer survival than those with low expression. Univariate and multivariate analyses showed that DEPTOR expression was an independent prognostic factor for DTC recurrence. In conclusion, our data indicate DEPTOR as a novel prognostic marker for DTC. IntroductionDifferentiated thyroid carcinoma (DTC) is the most common histological type of thyroid malignancy and its incidence is increasing (1). Although the majority of DTCs have a relative low mortality, with 10-year survival rates of 83-95%, approximately 30% of patients with DTC still undergo recurrence during the decades following initial therapy during several decades (2,3). Establishing relevant biomarkers with prognostic significance may prove crucial in reducing the recurrence rate and modifying therapeutic strategies for individual DTC patients (4). To date, few molecular prognostic indicators have been used to evaluate the efficiency of DTC patient diagnosis and prognosis (5,6).DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR), a recently identified 48 kDa mTOR-interacting protein, is a novel candidate oncogene (7). DEPTOR is capable of inhibiting mTORC1 signaling and activation of mTORC2 signaling (8-10). As the downstream signal of DEPTOR, mTORC2 protein complex displays PDK-2 activity leading to serine 473 phosphorylation and overactivation of the PI3K/Akt pathway (11,12). Many key functions of PI3K/Akt signaling, such as genetic mutations of kinases and regulatory proteins, epigenetic alterations and post-translational modifications, have already been confirmed by in vitro studies and clinical data in thyroid cancer and a wide variety of other tumors (13-15). The significant role of DEPTOR in regulating tumor growth and progression indicates that it may closely correlate with aggressive clinical behaviors of DTC.However, the expression level of DEPTOR in DTC is largely unknown and the role of DEPTOR in clinical progression remains to be established. Therefore, we evaluated DEPTOR expression on the mRNA and protein level in thyroid ca...
The role of PTPRT in breast cancer was not comprehensively explored and well analyzed. Our study comprehensively searched available databases to analyze the clinical role of PTPRT in breast cancer. We found PTPRT was an antioncogene and could be used to distinguish different stages, age groups, molecular types, and grades for breast cancer. PTPRT might be primary resistance biomarkers for taxane, anthracycline, and ixabepilone but not be acquired resistance biomarkers. Higher PTPRT expression levels were associated with longer overall survival and recurrence-free survival. PTPRT was negatively associated with Ki67 and CDK4/6 but positively associated with BCL-2. PTPRT might be associated with cell cycle and microtubule, and tumor infiltration in B cell and macrophage cell. PTPRT could predict chemotherapy effectiveness and prognosis for breast cancer patients. PTPRT might inhibit tumor growth via disrupting the microtubule dynamics and cell cycle in breast cancer.
China's rapid development of market economy and open market environment has brought a rare opportunity for development for Chinese enterprises nowadays, but also makes a lot of enterprises face a more intense challenge and competition at the same time. In the final analysis, the current economic competition is essentially a talent competition, Because of the human resources has the characteristics that it can not be copied, as well as its strong growth potential, big return space, it has become the primary resource and core competitiveness of enterprises. For today's enterprises, it is essential for the modern enterprise survival and development to exploit the potential of human resources fully. Development of talent advantage is closely related to human resource management, therefore, it's the key to fully understand the current situation of the quality of human resource management, and constantly improve the level of human resource management. Therefore, this article is committed to exploring specific programs of quality human resource managers forged.
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