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Aims To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity, and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients. Methods Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting‐state functional magnetic resonance imaging scans were performed, and fractional amplitude of low‐frequency fluctuations (fALFF) was calculated across different frequencies. The Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, and GM composition. Results aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different “GM‐intrinsic brain activity interaction” patterns. In aMCI group, at the typical band (0.01‐0.08 Hz), the relative abundance (RA) of Bacteroides from phylum to genus level was negatively correlated with fALFF value of cerebellar vermis IV‐V, and the Ruminococcaceae RA was negatively correlated with fALFF values of left lenticular nucleus and pallidum. The Clostridiaceae RA and Blautia RA were positively correlated with the left cerebellum lobules IV‐V at the slow‐4 band (0.027‐0.073 Hz). The Veillonellaceae RA was positively correlated with fALFF values of left precentral gyrus at the slow‐5 band (0.073‐0.08 Hz). Correlation analysis showed that Clostridium members (Lachnospiraceae and Blautia) were positively, while Veillonellaceae was negatively, correlated with cognition test. Bacteroides was positively correlated with attention and computation, and negatively correlated with the three‐stage command score. Conclusions aMCI patients have a specific GM‐intrinsic brain activity‐cognitive function interaction pattern.

Objective: This study aimed to determine the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on cerebral hemodynamics in patients with disorders of consciousness (DOC). Methods: In this sham-controlled study, 20-Hz and sham rTMS were applied over the left primary motor cortex (M1) of 5 patients in a vegetative state (VS) and 5 patients in a minimally conscious state (MCS). The clinical behavior and cerebral blood flow (CBF) velocity in the bilateral middle cerebral artery (MCA) of the patients were evaluated before and after rTMS. Results: Compared with the VS group, the MCS group exhibited significant increases in peak systolic velocity (PSV; p = 0.024) and mean flow velocity (MFV) of the left MCA that were temporally related to the rTMS (p = 0.042). There were no significant effects on CBF velocity in the sham-stimulation group or the right MCA. Conclusions: High-frequency rTMS exerts different effects on CBF depending on the level of consciousness in patients with DOC such that it increased PSV and MFV in patients in a MCS. These effects may be related to the varying degrees of disrupted neurovascular coupling and the autonomic control of the cerebral hemodynamics in patients in a VS or MCS.

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Tin disulfide (SnS2) shows promising properties toward sodium ion storage with high capacity, but its cycle life and high rate capability are still undermined as a result of poor reaction kinetics and unstable structure. In this work, phosphate ion (PO43−)‐doped SnS2 (P‐SnS2) nanoflake arrays on conductive TiC/C backbone are reported to form high‐quality P‐SnS2@TiC/C arrays via a hydrothermal–chemical vapor deposition method. By virtue of the synergistic effect between PO43− doping and conductive network of TiC/C arrays, enhanced electronic conductivity and enlarged interlayer spacing are realized in the designed P‐SnS2@TiC/C arrays. Moreover, the introduced PO43− can result in favorable intercalation/deintercalation of Na+ and accelerate electrochemical reaction kinetics. Notably, lower bandgap and enhanced electronic conductivity owing to the introduction of PO43− are demonstrated by density function theory calculations and UV–visible absorption spectra. In view of these positive factors above, the P‐SnS2@TiC/C electrode delivers a high capacity of 1293.5 mAh g−1 at 0.1 A g−1 and exhibits good rate capability (476.7 mAh g−1 at 5 A g−1), much better than the SnS2@TiC/C counterpart. This work may trigger new enthusiasm on construction of advanced metal sulfide electrodes for application in rechargeable alkali ion batteries.

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The study intends to identify the impact social media recruitment (SMR) on job candidates" overall perception (OP) in Bangladesh. For this purpose, the authors have employed two independent variables of SMR: perceived advantage (PA) and perceived ease of use (PEU) and three dependent variables: perceived privacy (PP), perceived fairness (PF) and perceived ethics (PE). 877 graduates have been selected through judgment sampling as participants who have completed graduation recently and are looking for jobs. Simple linear and multiple linear regressions have been applied to analyze the data. Afterwards, it was revealedthat all the two independent variables are positively correlated to all the three dependent variables. But in case of PE, the relationship is weak. Further, PA and PEU are positively related to overall perception (OP). The results might be proven important for those academicians want to further investigate in this relatively untapped area as well as for the HR practitioners to understand the perceptions of job seekers regarding social media recruitment.

Although amyloid-β (Aβ) peptide accumulation is considered as a key early event in the pathogenesis of Alzheimer’s disease (AD), the precise pathophysiology of this deadly illness remains unclear and no effective remedies capable of inhibiting disease progression have been discovered. In addition to deposition of extracellular Aβ plaques and intracellular neurofibrillary tangles, neuroinflammation has been identified as the third core characteristic crucial in the pathogenesis of AD. More and more evidence from laboratory and clinical studies have suggested that anti-inflammatory treatments could defer or prevent the occurrence of AD. In this review, we will discuss multifaceted evidence of neuroinflammation presented in AD and the newly emerged anti-inflammatory targets both in pre-clinical and clinical AD.