The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain

Huang, Jiayi; Lu, Ying; Wang, Huan; Li, Jun; Liao, Mei; Li, Hong; Tao, Rong; Ahmed, Muhammad Masood; Liu, Ping; Liu, Shuang shuang; Fukunaga, Kohji; Du, Yong; Han, Feng

doi:10.1016/j.biomaterials.2013.07.009

Cited by 41 publications

(26 citation statements)

References 54 publications

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“…Once internalized, nanomaterials may cause a broad range of biological effects such as inflammatory responses, oxidative stress, DNA damage and apoptosis (Huang et al, 2013;Kodali et al, 2013;Sahu et al, 2013;Song et al, 2009;Stebounova et al, 2011;Steuer et al, 2014;Stoccoro et al, 2013;Ucciferri et al, 2014). Silica nanoparticles, for instance, have been shown to induce reactive oxygen species autophagy in human hepatocytes (Mohammadi et al, 2014;Poggio et al, 2014), neurotoxicity and Alzheimer-like pathology in human and mouse neuronal cells (Yang et al, 2014), spermatogenesis damage (Xu et al, 2014) and impairment of vascular homeostasis (Nemmar et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Tedesco

Mičetić

Ciappellano

et al. 2015

Toxicology in Vitro

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Tedesco

Mičetić

Ciappellano

et al. 2015

Toxicology in Vitro

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“…It has been observed that uncoated lipid NPs, which accumulate in the brain parenchyma after intravenous injection, cause considerable microglia activation. PEG coating of those lipid NPs with PEG strongly reduce microglial activation [92].…”

Section: Discussionmentioning

confidence: 99%

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

et al. 2014

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Diagnostic-and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these "human-non-self" modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.

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“…Poly-nanoparticles such as PBCA-NPs [32][33][34][35] (butylcyanoacrylate), PEG [36][37][38][39][40] (polyethylene glycol), liposomes [41][42][43] , P-gp (P-glycoprotein), and even superparamagnetic iron oxide nanoparticles [37] have been used for drug delivery.…”

Section: Endotheliamentioning

confidence: 99%

Novel drug-delivery approaches to the blood-brain barrier

Wang

Vaughan

et al. 2015

Neurosci. Bull.

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The blood-brain barrier (BBB) maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies.

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The effect of lipid nanoparticle PEGylation on neuroinflammatory response in mouse brain

Cited by 41 publications

References 54 publications

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

Novel drug-delivery approaches to the blood-brain barrier

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