Purpose
We assessed the treatment outcome and the benefits of routine follow-up visits in T1 glottic laryngeal squamous cell carcinoma (LSCC).
Methods
Medical records of patients diagnosed with stage T1 glottic LSCC (N = 303) in five Finnish university hospitals between 2003 and 2015 were reviewed. Moreover, data from the Finnish Cancer Registry and the Population Register Center were collected.
Results
Of all 38 recurrences, 26 (68%) were detected during a routine follow-up visit, and over half (21 of 38, 55%) presented without new symptoms. Primary treatment method (surgery vs. radiotherapy) was not connected with 5-year disease-specific survival (DSS) or laryngeal preservation rate.
Conclusion
The majority of recurrences were detected on a routine follow-up visit, and local recurrences often presented without new symptoms. Routine post-treatment follow-up of T1 glottic LSCC seems beneficial.
Trial registration
Trial registration number and date of registration HUS/356/2017 11.12.2017.
Background
Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.
Methods
We analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow‐up.
Results
Elevated S‐MMP‐8 level in RRP was associated with malignant transformation (P = .01). Compared to patients with RRP, S‐MMP‐8 in patients with LSCC was significantly higher (P < .001). Increased S‐TIMP‐1 level in LSCC was associated with poor overall survival (P = .02) and recurrence‐free survival (P = .05).
Conclusion
In RRP, high S‐MMP‐8 may predict malignant transformation. In LSCC, elevated S‐TIMP‐1 is connected to poor survival.
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