T1 glottic laryngeal cancer: the role of routine follow-up visits in detecting local recurrence

Abstract

Purpose We assessed the treatment outcome and the benefits of routine follow-up visits in T1 glottic laryngeal squamous cell carcinoma (LSCC). Methods Medical records of patients diagnosed with stage T1 glottic LSCC (N = 303) in five Finnish university hospitals between 2003 and 2015 were reviewed. Moreover, data from the Finnish Cancer Registry and the Population Register Center were collected. Results Of all 38 recurrences, 26 (68%) were detected during a routine follow-up visit, and over half (21 of 38, 55%) presented without new symptoms. Primary treatment method (surgery vs. radiotherapy) was not connected with 5-year disease-specific survival (DSS) or laryngeal preservation rate. Conclusion The majority of recurrences were detected on a routine follow-up visit, and local recurrences often presented without new symptoms. Routine post-treatment follow-up of T1 glottic LSCC seems beneficial. Trial registration Trial registration number and date of registration HUS/356/2017 11.12.2017.

Narrow‐Band Imaging in Transoral Laser Surgery for Early Glottic Cancer: A Randomized Controlled Trial

“…The 5-year overall survival of early-stage laryngeal carcinoma reported in the literature is high: 88% to 94%, 19,24,31 and the reported 5-year disease-specific survival is even better 97% to 99%. 19,28,32 Although the survival is favorable, the recurrence rate is considerable: percentages between 10% and 31% are reported, 19,24,27,[33][34][35][36][37] which is consistent with the recurrence rate of 23% we found. The recurrence rate is largely dependent on the follow-up duration that was maintained in different studies, for instance, the recurrence rate of 31% was found in a cohort with a follow-up duration of 15 years.…”

Circular RNA circSLC7A11 contributes to progression and stemness of laryngeal squamous cell carcinoma via sponging miR-877-5p from LASP1

“…LSCC is characterized by local recurrence that seriously restricts LSCC therapy [ 20 , 21 ]. Thus, expanding our understanding of LSCC mechanisms provides effective targets for LSCC clinical therapy.…”

Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study

“…The potential prognostic value of mentioned hematological parameters regarding recurrence or progression of laryngeal dysplasia requires prospective, multicenter, randomized controlled studies to comprehensively evaluate the findings. The follow-up duration of 12 months seems to be quite short for the recurrence or cancerization observation; however the majority of the T1 glottic cancer relapses appear within first 24 months and are asymptomatic ( Pakkanen et al, 2021 ) Moreover, the late relapses are more dependent on continued exposure to risk factors. The early ones are more dependent on internal biological mechanisms.…”