A case of "hemicrania continua" after cluster headache in the same subject is described. Indomethacin exerted an absolute, persistent effect on the present headache. Even though our data are insufficient to demonstrate a causal relation between the two forms of headache, they do suggest this real possibility.
Aim: The purpose of this article is to prove the importance of autologous fat transfer (AFT) in scarring
alopecia.
Methods: We present a complete clinical report of 21 cases treated with a combined procedure of AFT and
hair transplantation (HT) done in the last three years.
Results: The main findings of this study are the constant, early and more predictable hair regrowth after the
hair transplant done on a pre-treated scarring alopecia.
Conclusion: Tissue regeneration through AFT can significantly improve hair growth in the area of scarring
alopecia, underlining, once again, the tremendous potential of this approach. Future studies may need to be
carried out.
Aim: The purpose of this article is to prove the possibility to transfer a good amount of cells of the SVF
(and ADSCs) in the infranatant portion of microfragmented adipose tissue.
Method: The adipose tissue harvesting procedure is performed under local anaesthesia. The adipose tissue
was harvested with a 2 mm diameter microperforated cannula with 1 mm side port holes, mounted inside
the special patented guide. Both cannula and guide are included in the SEFFIHAIR™ medical device. Once
the adipose tissue is harvested, it is gently washed, and it was divided in two specimens: (EMU) the tissue
was emulsified with 20 passages from one syringe to another and (CTRL) the tissue didn’t undergo any
emulsification.
Results: The emulsification procedure liberated alive and proliferating cells and we observed that the
specimens derived with a 1 mm side port hole cannula and then emulsified (EMU) showed a higher number
of cells in the infranatant part compared to the one derived from the control tissue without any (1 EMU vs.
1EMU infra).
Conclusion: The use of microcannulas, in combination with a mechanical digestion by an emulsification
procedure and centrifuge, could ease SVF cells isolation for regenerative treatment and could also be
performed in a medical facility.
Background: The aging process starts in the center of the face, in the periocular region and around the mouth, with a combination of volume loss, tissue descent, deepened wrinkles, and the loss of skin structure and quality. Recently, several studies have demonstrated the efficacy of therapies based on autologous adipose tissue grafting, which leverages the properties of stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (ADSCs) to accelerate the regenerative processes of the skin. This study aims to verify the ability of guided superficial enhanced fluid fat injection (SEFFI) in the facial area to correct volume loss and skin aging, proving that this standardized procedure has a very low rate of complications. Methods: We retrospectively collected data from 2365 procedures performed in Italian centers between 2019 and 2021. Guided SEFFI was performed alone or combined with cosmetic treatments, including the use of hyaluronic acid filler, suspension threads, synthetic calcium hydroxylapatite, botulin toxin, and microneedling. Results: guided SEFFI was used alone in more than 60% of the patients and in all facial areas. In about one-tenth of the patients, guided SEFFI was combined with a botulin toxin treatment or hyaluronic acid filling. Other procedures were used more rarely. Ecchymosis in the donor or injection sites was the most frequent adverse event but was only observed in 14.2% and 38.6% of the patients, respectively. Conclusions: The guided SEFFI technique is standardized and minimally invasive, leading to very few complications. It constitutes a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.
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