Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia

Gennai, Alessandro; Tesauro, Piero; Colli, Mattia; Zia, Silvia; Zattoni, Andrea

doi:10.31487/j.rgm.2021.01.01

Cited by 2 publications

(4 citation statements)

References 27 publications

(29 reference statements)

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“…Furthermore, it guarantees that the harvesting procedure is performed in a safe plane. The SEFFI cannula allows for collecting adipose tissue already in small cellular clusters avoiding any further mechanical manipulations while allowing high viability and stemness of the micro-fragmented adipose tissue [12,36]. The coding technique for the guided SEFFI use allowed physicians without surgical skills to perform the SEFFI technique in a coded, simple safe, and effective way.…”

Section: Discussionmentioning

confidence: 99%

“…Regenerative therapy exploits the properties of the cells of stromal vascular fraction (SVF) of the adipose tissue to counteract these aging-associated changes. However, regenerative medicine currently resorts to injecting adipose-derived stem cells (ADSCs) because of their characteristics and easy availability [12][13][14][15][16]. In the last years, several studies proved the efficacy of therapies based on the autologous grafting of adult mesenchymal stem cells to accelerate the healing and regenerative processes of the skin and mesenchymal tissues.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Gennai¹,

Baldessin²,

Melfa³

et al. 2023

Preprint

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Background: The ageing process starts in the center of the face, in the periocular region and around the mouth, with a combination of volume loss and tissue descent, wrinkles deepen, and loss of skin structure and quality. Recently, several studies proved the efficacy of therapies based on the autologous adipose tissue grafting that leverages the properties of stromal vascular fraction (SVF) and adipose derived mesenchymal stem cells (ADSCs) to accelerate the regenerative processes of the skin. This study aimed to verify the ability of the guided Superficial Enhanced Fluid Fat Injection (SEFFI) in the facial area to correct volume loss and skin aging and proved the very low rate of complications of this standardized procedure . Methods: we retrospectively collected data from 2,365 procedures performed in Italian centers between 2019 and 2021. Guided SEFFI was performed alone or combined with cosmetic treatments, including the use of hyaluronic acid filler, suspension threads, synthetic calcium hydroxylapatite, botulin toxin, and microneedling. Results: SEFFI was used alone in more than 60% of the patients, and in all face areas. In about one tenth of patients SEFFI was combined with botulin toxin treatment or hyaluronic acid filling. Other procedures were used more rarely. Ecchymosis in the donor or injection sites was the most frequent event, and yet observed in only 14.2% and 38.6% of patients, respectively. Conclusions: The SEFFI technique is standardized and minimally invasive, leading to very few complications. It can be a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Gennai¹,

Baldessin²,

Melfa³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, the guide guarantees that the harvesting procedure is performed in a safe plane. The SEFFI cannula allows for the collection of adipose tissue that is already in small cellular clusters, avoiding any further mechanical manipulations while supporting high viability and stemness of the microfragmented adipose tissue [ 12 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, regenerative medicine currently resorts to injecting adipose-derived stem cells (ADSCs) because of their characteristics and availability [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Report

Gennai

Baldessin²,

Melfa³

et al. 2023

Clinics and Practice

Self Cite

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Background: The aging process starts in the center of the face, in the periocular region and around the mouth, with a combination of volume loss, tissue descent, deepened wrinkles, and the loss of skin structure and quality. Recently, several studies have demonstrated the efficacy of therapies based on autologous adipose tissue grafting, which leverages the properties of stromal vascular fraction (SVF) and adipose-derived mesenchymal stem cells (ADSCs) to accelerate the regenerative processes of the skin. This study aims to verify the ability of guided superficial enhanced fluid fat injection (SEFFI) in the facial area to correct volume loss and skin aging, proving that this standardized procedure has a very low rate of complications. Methods: We retrospectively collected data from 2365 procedures performed in Italian centers between 2019 and 2021. Guided SEFFI was performed alone or combined with cosmetic treatments, including the use of hyaluronic acid filler, suspension threads, synthetic calcium hydroxylapatite, botulin toxin, and microneedling. Results: guided SEFFI was used alone in more than 60% of the patients and in all facial areas. In about one-tenth of the patients, guided SEFFI was combined with a botulin toxin treatment or hyaluronic acid filling. Other procedures were used more rarely. Ecchymosis in the donor or injection sites was the most frequent adverse event but was only observed in 14.2% and 38.6% of the patients, respectively. Conclusions: The guided SEFFI technique is standardized and minimally invasive, leading to very few complications. It constitutes a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.

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Infranatant Portion of Microfragmented Adipose Tissue: A Promising Source of SVF for the Management of Androgenetic Alopecia

Cited by 2 publications

References 27 publications

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Report

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